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Pharma 2018
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E u r o p e a n C o n g r e s s o n
Pharma
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
American Journal of Pharmacology and Pharmacotherapeutics
ISSN: 2393-8862
T
he recent investigations showed that
Portulaca Oleracea (P. oleracea)
has antioxidant with anti-inflammatory effects. This
study was carried out to investigate the effects of methanolic extract of
P. oleracea
against cadmium-induced nephrotoxicity
in rats. Male albino Wistar rats were randomly divided into nine experimental groups, as follows: Group 1 as a negative control
group were treated with normal saline; group 2 received single dose of 2 mg/kg cadmium for two consecutive weeks; groups
3-5 received a methanolic extract of
P. oleracea
in doses of 400, 600 and 800 mg/kg and 2 mg/kg cadmium, respectively for
two consecutive weeks. All administrations were performed intraperitoneally. Blood urea nitrogen (BUN) and serum creatinine
(Scr), were used to assess nephrotoxicity. Furthermore, the histopathological observations were used to evaluate the changes
of tissue. The findings showed that the administration of cadmium leads to a significant increase in the levels of BUN and Scr
in comparison to normal saline group (p < 0.05). Treated group by the extract of
P. oleracea
significantly altered these changes
to almost normal (P<0.05). In addition, these findings were supported and confirmed by histological examination. These results
suggest that
P. oleracea
extract may be useful in cadmium-induced renal toxicity and might serve as a novel preservative to limit
renal injury
.
Dr.babaei1981@yahoo.comProtective effect of hydroalcoholic extract of
Portulaca Oleracea against cadmium induced
nephrotoxicity
Javad babaei
Valiasr Hospital, Iran
Am J Pharmacol Pharmacother 2018, Volume 5
DOI: 10.21767/2393-8862-C1-003