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Pharma 2018
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E u r o p e a n C o n g r e s s o n
Pharma
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
American Journal of Pharmacology and Pharmacotherapeutics
ISSN: 2393-8862
R
isperidone nanoemulsion using different mucoadhesive agent as nasal drug delivery system was prepared to produce quick
effect as compared to that of oral route. Solubility of drug was determined in different vehicles. Pseudo ternary phase diagram
were generated using Acrysol K 150 as oil, tween 80 as a co-surfactant, and caproyl PGMC as a surfactant. The four formulations
were prepared by the spontaneous emulsification method and were further characterized for their percentage transmittance,
droplet size and zeta potential. Ex vivo diffusion study of the optimized batch was carried out using goat nasal mucosa.
Histopathological study of the optimized batch was studied. Optimized formulation was found to possess the mean globule size
149 mm and zeta potential -17.3 mV.
Ex vivo
study revealed that at the end of 4 h, 93.76% of the dose was diffused successfully.
In the histopathological study, formulation treated mucosa did not show any damage to the epithelium layer
.
drashti72009@gmail.comNanoemulsion based intranasal delivery of
risperidone for nose to brain targeting
Drashti G Pathak
1
, Shailesh T Prajapati
2
and Sarjak P Pathak
2
1
Parul Institute of Pharmacy and Research, Parul University, Gujarat
2
Shri Sarvajanik Pharmacy College, Gujarat Technological University, Gujarat
Am J Pharmacol Pharmacother 2018, Volume 5
DOI: 10.21767/2393-8862-C1-003