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Pharma 2018
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E u r o p e a n C o n g r e s s o n
Pharma
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
American Journal of Pharmacology and Pharmacotherapeutics
ISSN: 2393-8862
C
ognitive deficit is an emerging health concern in diabetic patients and hyperglycemia and reactive oxygen species are well
believed to be among the prime candidates mediating the behavioral impairments and memory deficits. The study was
conducted to evaluate the effect of hyperglycemia on spatial working memory and social memory on Swiss albino mice. The
animals were divided into three (3) groups of six each (n=6). Group I served as normal control and received distilled water,
group II, and III were hyperglycemic. Hyperglycemia was induced using Alloxan (150 mg/kg). All administrations were done
intraperitoneally. A digital glucometer was used to determine the blood glucose level. Spatial working memory and social memory
were assessed using spontaneous alternation in the Y-maze and novel object recognition task (NORT) respectively. The results
showed that hyperglycemia significantly (p < 0.05) induces spatial working memory and social memory deficits when compared
to control. This study demonstrated that hyperglycemia induces cognitive impairment in both spatial working memory and social
memory
.
garkus_ua@yahoo.comHyperglycemia induces spatial working memory and
social memory impairments in Swiss albino mice
Usman Adamu Garkuwa
1, 2
, Yusuf Tanko
2
, Alhassan AWahab
2
,
Nura G Adamu
3
, Buhari Ibrahim
1
, Bello Y Adamu
1
,
Abbas Ibrahim
1
and Ahamd A Ladan
1
1
Bauchi State University, Gadau, Nigeria
2
Ahmadu Bello University, Zaria, Nigeria
3
Gombe State University, Nigeria
Am J Pharmacol Pharmacother 2018, Volume 5
DOI: 10.21767/2393-8862-C1-003