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Pharma 2018
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E u r o p e a n C o n g r e s s o n
Pharma
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
American Journal of Pharmacology and Pharmacotherapeutics
ISSN: 2393-8862
F
ast-dissolving formulations represent excellent opportunities for life cyclemanagement to the pharmaceutical companies. Fast
dissolving technologies have many advantages like ease of swallowing, administration without water, quick onset of action for
improving both patient convenience and compliance as benefits for the patient; extended life cycle, product differentiation, patent
protection as benefits for pharmaceutical companies. But there are some challenges for formulation development studies like
taste-masking, disintegration time, moisture sensitivity, friability, packaging and intellectual property issues, especially for the
generic companies. The technologies are under patent protection like Zydis® , Flashtab®, OraSolv® and DuraSolv™, WOWTAB®.
One of the major issues is taste-masking problem that may be overcome with using cyclodextrins, polymer coating, flavouring
and sweetening agent, microencapsulation techniques. There are some modified excipients for providing both taste-masking
and productability properties in the formulation like Ludiflash®, Pharmaburst®. From the analytical development point of view,
there are a number of different methods from conventional dosage forms which are determined in the pharmacopoeias and for
comparison and assessment of taste masking, electronic tongue may be a good opportunity which was developed by Alpha M
O S. In the sense of generic companies, developing a fast dissolving tablets version of an existing immediate-release product
means that the two formulations must be bioequivalent and this can be challenging for
in-vivo
studies especially if the method
of taste masking retards the dissolution rate of the active ingredient after disintegration. What about the future of fast dissolving
technologies? Orally disintegrating extended Release (ODT-ER) dosage forms are providing all of the benefits of these two drug
delivery technologies in a single pharmaceutical product and oral rapid films also may be a good alternative, especially for the
OTC market
.
gulayelken@gmail.comFAST DISSOLVING DRUG DELIVERY SYSTEMS
Gulay Yelken Demirel
1, 2
1
Yeditepe University, Istanbul, Turkey
2
Sanovel Pharmaceuticals, Istanbul, Turkey
Am J Pharmacol Pharmacother 2018, Volume 5
DOI: 10.21767/2393-8862-C1-003