pharma-2018-posters-abstracts

Pharma 2018

Page 45

E u r o p e a n C o n g r e s s o n

Pharma

A u g u s t 1 3 - 1 4 , 2 0 1 8

P a r i s , F r a n c e

American Journal of Pharmacology and Pharmacotherapeutics

ISSN: 2393-8862

e have designed a microemulsion (ME) containing Ketoprofen (KET) for anti-inflammatory effect evaluated using the rat

paw edema model. The ME was prepared by adding propylene glycol (PG) loaded with 1% KET/water (3:1, w/w), to a mixture

of sorbitan monooleate and polysorbate 80 (47.0%) at 3:1 (w/w) and canola oil (38.0%). The physicochemical characterization of

KET-loaded ME involved particle size and zeta potential determination, entrapment efficiency, calorimetric analysis, and

in vitro

drug release. The

in vivo

anti-inflammatory study employed male Wistar rats. Measurement of the foot volume was performed

using a caliper immediately before and 2, 4, and 6 h after injection of Aerosil. KET-loaded ME showed particle size around 20

nm, with zeta potential at -16 mV and entrapment efficiency at 70%. Moreover, KET was converted to the amorphous state when

loaded in the formulation and it was shown that the drug was slowly released from the ME. Finally, the

in vivo

biological activity

was similar to that of the commercial gel, but ME better controlled edema at 4 h. These results demonstrated that the ME

formulation is an alternative strategy for improving KET skin permeation for anti-inflammatory effect. Furthermore, our findings

are promising considering that the developed ME was loaded with only 1% KET, and the formulation was able to keep a similar

release profile and

in vivo

effect compared to the commercial gel with 2.5% KET. Therefore, the KET-loaded developed herein ME

is likely to have a decreased side effect compared with that of the commercial gel, but both presented the same efficacy

Micro emulsion for improved skin delivery and in

vivo anti-inflammatory effect

Praca FSG

, Bentley MVLB

and Medina WSG

University of São Paulo, Brasil

University of Padre Albino, Brasil

Am J Pharmacol Pharmacother 2018, Volume 5

DOI: 10.21767/2393-8862-C1-003