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Pharma 2018
Page 48
E u r o p e a n C o n g r e s s o n
Pharma
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
American Journal of Pharmacology and Pharmacotherapeutics
ISSN: 2393-8862
T
he aim of present investigation was to develop press coated tablet for pulsatile drug delivery of Salbutamol sulphate using
hydrophilic and hydrophobic polymers. The drug delivery system was designed to deliver the drug at such a time when it
could be most needful to patient of rheumatoid arthritis. The press coated tablets containing salbutamol sulphate in the inner
core was formulated with an outer shell by different weight ratio of hydrophobic polymer (micronized ethyl cellulose powder)
and hydrophilic polymers (Glycinemax Husk or sodium alginate). The release profile of press coated tablet exhibited a lag time
followed by burst release, in which outer shell ruptured into two halves. Authors also investigated factors influencing on lag
time such as particle size and viscosity of ethyl cellulose, outer coating weight and paddle rpm. The surface morphology of
the tablet was examined by a scanning electron microscopy. Differential scanning calorimeter and Fourier transformed infrared
spectroscopy study showed compatibility between salbutamol sulphate and coating material
.
sagarkadam1111@gmail.comFormulation and evaluation of chronotherapeutic
pulsatle drug delivery system
Sagar D Kadam
1
, Shashikant Dhole
2
and Sohan Chitlange
3
1
Savitribai Phule Pune University, H S B P V T’s GOI, College of Pharmacy, Kashti, Maharashtra, India
2
S N Dhole Savitribai Phule Pune University, P E S, Modern College of Pharmacy, Pune, India
3
Savitribai Phule Pune University, Dr D Y Patil Institute of Pharmaceutical Sciences & Research,
Pune, India
Am J Pharmacol Pharmacother 2018, Volume 5
DOI: 10.21767/2393-8862-C1-003