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Pharma 2018
Page 39
E u r o p e a n C o n g r e s s o n
Pharma
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
American Journal of Pharmacology and Pharmacotherapeutics
ISSN: 2393-8862
B
iodegradable microspheres may develop improved drug delivery system to gastrointestinal tract for treatment of diabetes.
Metformin hydrochloride having the ability to produce effect for extended period were prepared using ethyl cellulose and
polyvinyl alcohol as the retardant material with entrapment efficiency and extended release using solvent evaporation techniques.
Microspheres were prepared by the double emulsification technique (W/O/W). A mixed solvent system of water and chloroform
contains metformin, ethyl cellulose and PVA in the ratio of (1:2:1) respectively. The product with a yield (50%) was investigated
under immersion lens with magnification of 40X using immersion oil. The prepared microspheres were characterized by drug
loading and showed a low entrapment. Microspheres were examined by optical microscopy, the size and the external features of
particles determined. The microspheres indicated a mean microsphere size 100 µm in diameter. IR study was carried out to check
the compatibility between the selected polymer and metformin hydrochloride. This study was performed to assure that there is
complete physical entrapment of the drug into the polymer without any mutual interaction. The DSC and XRD studies proved
that, there was retention of the crystalline nature of the drug in solid dispersion ruling out any probability of drug and polymer
interaction or complex formation. Initial in vitro experiments are under taken to examine the release profiles of metformin HCl
from microspheres in phosphate buffer at 37°C, pH 6.4, the process is followed up to 8 hrs by which the particles mass is eroded
.
Akashaabdu@yahoo.co.ukSustained release of metformin hydrochloride
microspheres for oral drug delivery system
Abdulrhman A Akasha
Tripoli University, Libya
Am J Pharmacol Pharmacother 2018, Volume 5
DOI: 10.21767/2393-8862-C1-003