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Pharmacognosy 2018
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 58
April 16-17, 2018
Amsterdam, Netherlands
6
th
Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Statement of the Problem:
Inflammation is the succession
change occurring in a living tissue when it is injured by physical
trauma, noxious chemicals or microbiological agents. Most of
the synthetic drugs used for treatment of inflammation cause
many side effects and toxic effects. Thus, many researches
was undertaken to find the anti-inflammatory activity with less
adverse effects. The objective of the present study to investigate
and compare the anti-inflammatory potential of
Ziziphus spina-
christi
and
Boswellia serrata
dry distillates.
Methodology:
The dry distillates were prepared by dry distillation
method. Anti-inflammatory activity of the distillates had been
tested in rats by Carrageenan-induced paw edema model.
Acute inflammation was produced by injecting 1% solution of
Carrageenan into the plantar surface of the rat right hind paw at
the dose of 0.1mL per 100g body weight. The rats were divided
into six groups of five rats each. Group I received normal saline
control (P.O) at a dose of 10ml/kg. Group II was treated with the
standard drug sodium diclofenac (20 mg/kg, P.O.). Group III and \
IVwere treatedwith extracts of
Z. spina-christi
200 and 400mg/kg
P.O doses, respectively. Group V and VI were treated with extracts
of
B. serrata
200 and 400 mg/kg P.O doses, respectively. After 60
minutes, Carrageenan solution was injected to the animals of all
groups. The paw size was measured using a digital clipper and
compared with control animals which received only the vehicle.
GC-MS was used for chemical analysis.
Findings:
The results showed significant anti-inflammatory
effect with p-values (0.000–0.009) and (0.002–0.45) for
Z. spina-
christi
and B. serrata, respectively which were found be dose and
time dependent. GC/MS analysis revealed the presence of 90
compounds in
Z. spina-christi
distillate and hundred compounds
were identified in
B. serrata
withmajor compounds well known for
their anti-inflammatory effect.
Conclusion & Significance:
The dry distillate of
Z. spina-christi
and
B. serrata
were found to have anti-inflammatory activity and
the activity was found to be higher in Z. spina-christi.
Recommendations: Further investigations regarding the
pharmacokinetics and pharmacodynamics of active constituents
of these plants should be done.
Recent Publications
1. Setorki M (2016) Effect of hydro-alcoholic extract of
Ziziphus spina-christi against scopolamine-induced
anxiety in rats. Bangladesh Journal of Pharmacology
11(2):421–427.
2. Boonyarikpunchai W, Sukrong S and Towiwat P (2014)
Antinociceptive and anti-inflammatory effects of
rosmarinic acid isolated from Thunbergia laurifolia Lindl.
Pharmacol Biochem Behav 124:67–73.
3. Kumar S, Bajwa B, Kuldeep S and Kalia A (2013) Anti-
inflammatory activity of herbal plants: A review. Int J Adv
Pharm Biol Chem. 2(2):272–281.
4. Siddiqui M (2011)
Boswellia serrata
, a potential anti-
inflammatory agent: an overview. Indian Journal of
Pharmaceutical Sciences 73(3):255–261.
5. Aman U and Balu G (2009) Pharmacological activities
of
Boswellia serrata
Roxb. —Mini review. Journal of
Ethnobotanical Leaflets 13:766–74.
Biography
Sara Nadi Joseph Wisa has her expertise in evaluation and passion in re-
search, search and discovery of natural drugs from plant origin. Her open
and contextual evaluation model based on responsive constructivists cre-
ates new drugs for improving and treating of infectious diseases
sara.wisa@yahoo.comA comparative study of anti-inflammatory activity and chemical
analysis of Ziziphus spina-christi leaves and Boswellia serrata
gum dry distillates
Sara Nadi Joseph Wisa
and
Ikram Mohamed Eltayeb
University of Medical Sciences and Technology, Sudan
Sara Nadi Joseph Wisa et al., Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-005