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Pharmacognosy 2018 American Journal of Ethnomedicine
ISSN: 2348-9502 Page 55
April 16-17, 2018
Amsterdam, Netherlands
6th Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Statement of the Problem: Hypothyroidism is a condition in which
the thyroid gland does not produce enough thyroid hormones
[triiodothyronine (T3) and thyroxine (T4)] which is commonly
caused by iodine deficiency. It is a potentially serious disorder
and if left untreated it can lead to memory loss or mental slowing
as well as depression and may become more severe over time.
The current medical therapies for hypothyroidism are often
deemed inadequate because of difficulties in regulating the level
of thyroid hormones through use of conventional drugs. Herbal
drugs have proven to be useful in number of diseases, and they
have the capacity to cure suchmetabolic disorders synergistically
at different steps. Therefore, more research must be done for
effective and safer anti-hypothyroidism agent from plants. The
purpose of this study is to know whether Lepidium sativum would
affect the level of thyroid hormones.
Methodology: The extract was prepared by Soxhlet apparatus.
The anti-hypothyroidism activity was tested using thirty male
Wistar rats. They grouping into five groups, Group 1: Normal
group=administered only distilled water. Then 10 mg/kg
propylthiouracil was added to thedrinkingwater of all other groups
to induce hypothyroidism. Group 2: Negative control without any
treatment; Group 3: Test group=treated with oral administration
of 500 mg/kg extract; Group 4: Treated with oral administration
of 250 mg/kg of the extract; Group 5: Standard group (positive
control)=treated with intraperitoneal levothyroxine. All rats were
incubated for 20 days at animal house with room temperature of
proper ventilation provided with standard diet.
Findings: The results show that the L. sativum extract was found
to increase the T3 and T4 in the propylthiouracil induced rats with
values (0.29 ng/dl T3 and 0.57 U T4) for the 500mg/kg and (0.27
ng/dl T3 and 0.517 U T4) for the 250mg/kg in comparison with
standard with values (0.241 ng/dl T3 and 0.516 U T4) so that
L. sativum can be stimulatory to thyroid function and possess
significant anti-hypothyroidism effect with p-values ranges from
(0.000006*–0.893472).
Conclusion & Significance: L. sativum extract was found to
possess anti-hypothyroidism effects and act as an agent that
stimulates thyroid hormone secretion.
Recommendations: Further investigation should be carried to
investigate the anti-hypothyroidism effect of L. sativum extract at
the compound level.
Recent Publications
1. ManjariD,NeerajKandLNG(2017)Nutritionalimportance
of Lepidium sativum L. (Garden cress/Chandrashoor): A
review. International Journal of Pharmacy and Analytical
Research 5(1):152–160.
2. Carlé A, Pedersen I B, Knudsen N, Perrild H, Ovesen L,
et al. (2014) Hypothyroid symptoms and the likelihood
of overt thyroid failure: A population-based case control
study. Eur J Endocrinol 171:593–602.
3. Parle J, Roberts L and Wilson S (2010) A randomized
controlled trial of the effect of thyroxine replacement on
cognitive function in community-living elderly subjects
with subclinical hypothyroidism: the Birmingham elderly
thyroid study. J Clin Endocrinol Metab. 95:3623–32.
4. Mummenhoff K, Polster A, Mühlhausen A and Theißen
G (2009) Lepidium as a model system for studying the
evolution of fruit development in Brassicaceae. Journal
of Experimental Botany 60(5):1503–13.
5. Monzani F, Di Bello V and Caraccio N (2001) Effect
of levothyroxine on cardiac function and structure in
subclinical hypothyroidism: a double blind, placebo-
controlled study. J Clin Endocrinol Metab 86:1110–5.
Biography
Reham Sharfeldeen Osman has her expertise in evaluation and passion in re-
search, search and discovery of natural drugs from plant origin. Her open and
contextual evaluation model based on responsive constructivists creates new
drugs for improving and treating of infectious diseases
Anti-hypothyroidism activity of Lepidium sativum ethanolic extract
Reham Sharfeldeen Osman and Ikram Mohamed Eltayeb
University of Medical Sciences and Technology, Sudan
Reham Sharfeldeen Osman et al., Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-005