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Pharmacognosy 2018 American Journal of Ethnomedicine
ISSN: 2348-9502 Page 56
April 16-17, 2018
Amsterdam, Netherlands
6th Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Statement of the Problem: Cardiovascular diseases play a
central role in mortality and morbidity rates around the world.
Dyslipidemia and oxidative stress are considered modifiable
risk factors of cardiac diseases. Pharmacologic activities of
the plants’ extracts were demonstrated in previous researches.
The purpose of this study is to analyze extracts using GC-MS to
identify active principles and percentages of their occurrence in
analytes.
Methodology: Analysis of the crude 96% ethanolic extracts was
performed using (GS-MS QP) type Schimadzu 2010 with capillary
column RTX-50 (restec), (length 30 mm, diameter 0.25 mm, and
thickness 0.25 mm). Helium used as carrier gas, temperature
programmed at 200°C for 5 minutes at rate of 15ml/minute,
extracts were injected using split injection mode. Identification of
different components was from their mass Spectra and retention
time, compared with those on NIST library.
Findings:Revealedpresence of 80 compounds in extract of locally
grown C. reticulata, abundant in monoterpenoid compounds
including limonene (3.03%), alpha and gamma–terpinenes
(2.61%), linalool (1.38%), citral (1.72%) having anti-oxidant
effects. Sesquiterpenoids, humulene (0.26%) and caryophyllene
(1.97%) were identified. Locally grown S. indicum oil and water
soluble portions of extract revealed presence of 64 compounds
with high percentage of monounsaturated fatty acid ester methyl
oleate (66.99%), methyl stearate (9.35%) and palmitate (15.71%)
in oil portion, whereas, plant sterols; Gamma-sitosterol (13.5%),
fucosterol (2.11%), stigmasterol (1.95%) and gamma-tocopherol
(1.16%) occurred in water-soluble portion. Z. officinale rhizome
analysis revealed presence of 93 compounds, including alpha-
zingeberine (16.5%), gingerol (9.25%), alpha- sesquiphellandrene
(8.3%), zingerone (6.78%), beta-bisabolene (4.19%), alpha-
farnesene (3.56%), ar-curcumene (3.29%), gamma- elemene
(1.25%) and other compounds.
Conclusion & Significance: The study demonstrated presence
of compounds having antioxidant activity, effects on intestinal
cholesterol absorption and regulation of serum cholesterol levels
which reflects activities of extracts. Evaluation of the extracts’
pharmacologic activities at individual compound level is required
to assess their potential as prospective therapeutic agents.
Recent Publications
1. QidwaiW, JahanF andNanji K (2014) Roleof complementary
and alternative medicine in controlling dyslipidemia.
Evidence-Based Complementary and Alternative Medicine.
14(2):1–2.
2. Tomar A, Mall M and Rai P (2013) Pharmacological
importance of citrus fruits. International Journal of
Pharmaceutical Sciences and Research 4(1):156–60.
3. Dar A A and Arumugam N (2013) Lignans of sesame:
Purificationmethods,biologicalactivitiesandbiosynthesis–a
review. Bioorganic Chemistry 50(1):1–10.
4. Banerjee S, Mullick H, Banerjee J, Ghosh A (2011)
Zingiber officinale: ‘a natural gold’. International Journal of
Pharmaceutical and Bio- Sciences 2(3):283–94.
5. Suja K P, Jayalekshmy A and Arumughan C (2004) Free
radical scavenging behavior of antioxidant compounds of
sesame (Sesamum indicum L.) in DPPH system. Journal of
Agricultural and Food Chemistry 52(4):912–5.
Biography
Samar Saadeldin Abdelmotalab has her passion in improving the health and well-
being in Sudan. Her research was based on the evaluation of the pharmacologic
properties of locally grown and imported plants and analysis of the active constit-
uents of these plants. The research which she conducted won the university prize
as the best one held in Faculty of Pharmacy in the year of her graduation, 2015.
Since then she has been conducting her national country service at the National
Medicines and Poisons Board. She wishes to continue her studies in attaining
Master’s Degree and further development in the field of Pharmaceutical Sciences
Gas chromatographic – mass spectroscopic analysis of Citrus reticulata
fruit peel, Zingiber officinale rhizome and Sesamum indicum seed ethanolic
extracts possessing antioxidant activity and lipid profile effects
Samar Saadeldin Abdelmotalab, Sudan Ikram Mohammed Eltayeb and Saad Hus-
sein Ayoub
University of Medical Sciences and Technology, Sudan
Samar Saadeldin Abdelmotalab et al., Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-005