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Pharmacognosy 2018 American Journal of Ethnomedicine
ISSN: 2348-9502 Page 45
April 16-17, 2018
Amsterdam, Netherlands
6th Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Pometia pinnata is a plant belonging to the Sapindaceae family
that is found in eastern Indonesia such as Papua, Sulawesi
and Maluku with the local name of matoa. Empirically, matoa is
used as a traditional used as an antidiabetic. The purpose of this
study was to determine the in vitro antidiabetic activity of aqueous
and ethanol extract from the leaf and bark of matoa. The material
used in this study was obtained from Manado, North Sulawesi,
Indonesia. The aqueous extract was prepared by boiling the
powder of thematerial inwater at 90°C for 15minutes, andethanol
extract by maceration in 70% ethanol. Phytochemical analysis
showed that leaf and bark of matoa contains saponins, tannins,
flavonoids and triterpenoids. The in vitro antidiabetic activity test
was performed by the α-glucosidase inhibitory activity method
with p-nitrophenyl-α-D-glucopyranoside substrate and measured
by UV-V spectrophotometer at 400 nm. The α-glucosidase
enzyme was obtained from Saccharomyces cerevisiae. The
results showed that the leaf and bark aqueous extract of matoa
had antidiabetic activity by α-glucosidase inhibition with IC50
value of 9.74 µg/ml and 10. 65 µg/ml, while the ethanol extract of
leaf and bark of matoa 10.32 µg/ml and 8.34 µg/ml.
Recent Publications
1. T Rachmatiah, et al. (2009) (+)-n-(2-hydroxypropyl)
lindcarpine: A new cytotoxic aporphine isolated from
Actinodaphne pruinosa Nees. Molecules 14(8):2850–
2856.
2. Tiah Rachmatiah, et al. (2009) Bisbenzylisoquinoline
alkaloids from the bark of Actinodaphne pruinosa
Nees. Malaysian Journal of Science 28:75–80.
3. Soleh Kosela, Li-Hong Hu, TiahRachmatia, et al.
(2000) dulxanthones f−h, three new pyranoxanthones
from Garcinia dulcis, Journal of Natural Products
63(3):406–407.
4. Soleh Kosela, Li-HongHu, See-Chung Yip, Tiah
Rachmatia, et al. (1999) Dulxanthone E: A
pyranoxanthone from the leaves of Garcinia dulcis,
Phytochemistry 52(7):1375–1377.
Biography
Tiah Rachmatiah is working at the Faculty of Pharmacy, Institut Sains dan
Teknologi Nasional, Indonesia as a Lecturer in several courses including Or-
ganic Chemistry and Phytochemistry. She is interested in the field of Natural
Products and the research that she did cover the fields related to natural
products such as chemical content of plants and bioactivities of plants.
The in vitro antidiabetic activity of leaf and bark of matoa
(Pometia pinnata J. R. & G. Forst) by alpha-glucosidase inhibitory
activity
Tiah Rachmatiah and Christine E Poputra
Institut Sains dan Teknologi Nasional, Indonesia
Tiah Rachmatiah et al., Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-005