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Pharmacognosy 2018
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 39
April 16-17, 2018
Amsterdam, Netherlands
6
th
Edition of International Conference on
Pharmacognosy and
Medicinal Plants
H
ypertension has been acknowledged as one of the highest
risk factors leading to cardiovascular diseases (CVD).
Angiotensin-converting enzyme (ACE) has been demonstrated
as the therapeutic target for hypertension-based CVD
treatment. Anti-hypertension bioactivity ingredients screening
and development has become a pharmaceutical treatment
for the CVD. Many kinds of herbal, such as pine needle, a
traditional Chinese medicine, have been used for the treatment
of hypertension since ancient, but the bioactive agent which
is responsible for its therapeutic effectiveness remain unclear.
Therefore, screening bioactive chemicals from natural
sources is still the most straightforward strategy for novel
ACE inhibitor-based anti-hypertension agent discovery. In
this study, we demonstrated a bioactivity-guided fractionation
strategy for identifying bioactive fractions and chemicals from
pine needle based on LC/MS assay as well as elucidating their
mechanisms of pharmacological activity. The compound in
pine needle extracts being ACE-inhibitory active was found
to be catechin. When ACE activity was assayed in rat tissue
membranes, it was observed that catechin demonstrate ACE
inhibition in kidney, lung and testes tissue. These observations
indicate that catechin in pine needle could be a potential
cardiovascular medicine.
jih003@sjtu.edu.cnCatechin from pine needle act as an anti-hypertension agent
Jian He
Shanghai Jiao Tong University, China
Jian He, Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-005