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Pharmacognosy 2018
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 99
April 16-17, 2018
Amsterdam, Netherlands
6
th
Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-006
S
wietenia mahagoni
is a medicinal plant used in various
medicinal practices for the treatment of various human
ailments. Present study evaluates the anti-diabetic potential of
Swietenia mahagoni
aqueous extract (MAE) in fructose induced
diabetic rats with insulin resistance. Diabetes was induced in
the rats by treating the rats with 20% fructose (W/V) in drinking
water for 40 days. Diabetes and hyperinsulinemic condition was
confirmed by assessing the glucose and insulin levels in the
blood of the experimental rats. After the confirmation of diabetic
condition, rats were treated with the MAE and the standard drug
metformin and one group was left without any treatment and
labelled as positive control. MAE treatment improved glucose
levels, reduced insulin levels, improved insulin sensitivity,
improved glucose tolerance, improved pancreatic β-cell health,
decreased glycated hemoglobin content, reduced lipid peroxides,
improved glycogen content and activity of enzymes involved in
the synthesis of glycogen in the liver. There were also overall
improvements in anti-oxidant status (improved levels of vitamin
C, SOD and catalase and decreased amount of lipid peroxides)
of the treated groups when compared with the diabetic control.
The treatment also improved the lipid profile (improved HDL and
lowered LDL and triglycerides) of diabetic rats. Results confirmed
the anti-diabetic potential of MAE in animal models indicating its
scope for use as diabetic adjuvant in T-2 diabetic subjects.
navee.yp@gmail.comNormalization of insulin resistance, glucose intolerance and
lipid profile by Swietenia mahagoni leaf extract in fructose
induced diabetic rats
Naveen Y P
and
Asna Urooj
University of Mysore, India