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Pharmacognosy 2018
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 94
April 16-17, 2018
Amsterdam, Netherlands
6
th
Edition of International Conference on
Pharmacognosy and
Medicinal Plants
T
he present study reports the chemotypic variability of
bioactive alkaloids (colchicine and gloriosine) and phenolics
(quercetin and kaempferol) through calibrated HPTLC method
in
Gloriosa superba L
. (tuber), collected from 17 locations of
Central India and Gangetic plains. The effect of phytogeography
on their antioxidant and anti-inflammatory potential was also
established. Quantification data reveals that the content of
colchicine (COL) and gloriosine (GLO) varies from 0.02–0.513%
and 0.028–0.165%, respectively. Maximum content of colchicine
and gloriosine was reported in NBG-10 (Kanth, U.P) and NBG- 11
(Mohanlalganj, U.P) having 0.513% and 0.165%. Quercetin and
kaempferol content varies from 0.0007% to 0.122% and 0.005%
to 0.075%, with is maximum report in NBG-13 (Bheragha, M.P)
germplasm. The investigated test extract showed promising
antioxidant activity which was found in significant correlation
to total phenolic and flavonoid contents. Although varied results
were observed against
in vitro
anti-inflammatory activity, the best
results were observed in NBG-01 (0.0038%), whereas, lowest
activity was observed in NBG-78 (0.0117%). Based on statistical
evaluation on quantative analysis of bioactive metabolites and
bioactivity, five germplasmwere identified as elite chemotypes of
G. superba (NBG-1, NBG-10, NBG-11 and NBG-13) in the targeted
phyto-geography. Furthermore, our study proves significant
variability in biological potential of G. superba extract with the
change in phytogeographical content. Thus, it will aid in site
specific exploration of high metabolite yielding chemotype(s)
with validated pharmacological action to meet out the medicinal
and commercial demands.
anku.mis@gmail.com.Impact of geographical variation on chemotypic variability
and biological potential of Gloriosa superba L. collected from
Gangetic plains and Central India
Ankita Misra
1
, Sharad Srivastava
1
and
Pawan Kumar Agrawal
2
1
CSIR-National Botanical Research Institute, India
2
National Agriculture Science Fund — ICAR, India
Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-006