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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 71
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
C
D8+ T cell exhaustion is a hallmark of chronic viral infection.
Mechanisms underlying CD8+ T cell exhaustion, is still moot.
Upregulation of inhibitory receptors (i.e. PD-1, CTLA-4, Tim3) is the
major explanation how CD8+ T cells are dampened during chronic
viral infection. However, PD-1 is up-regulated on basically all activated
CD8+ T cells and
in vitro
data showed limited inhibition of proliferation
in the presence of its ligand, PD-L1, so that it remains elusive whether
other mechanisms contribute to PD-1 dependent failure of CD8+ T cell
function. Commensurately, protective immune responses against viral
infection are generally accompanied with production of autoantibodies
that might jeopardize the host. In the current study, we propose that
induction of autoantibodies during viral infections might attack CD8+
T cells, through binding to the cytotoxic T-cells and deplete them by
NK cell mediated cytotoxicity. The scope of our proposed study is to
delineate the underlying mechanism of T cells attack/exhaustion via
NK cell mediated cytotoxicity and to find out if the depletion of NK
cells, B cells or lack of Fc-receptor signaling blunt CD8+ T cell deletion,
culminating in robust CD8+ T cell response and effective control of
viral infection.
Autoantibodies are induced during chronic viral infection and
account to CD8+ T cell exhaustion
Thamer A Hamdan, Vikas Duhan and Karl S Lang
University of Duisburg-Essen, Germany
Biography
Thamer A Hamdan has completed his Bachelor’s degree in Medical
Laboratory Sciences from Jordan University of Science and Technology
in 2005. In 2007, he affiliated the same institute to pursue his Master’s
degree major in Clinical Microbiology and Immunology and obtained the
degree in 2010. From 2006-2011, he has worked as Medical Laboratory
Technologist at King Abdulla University Hospital, Jordan. Later, he has
worked as a Lecturer in Faculty of Applied medical Sciences in University
of Tabuk, Kingdom of Saudi Arabia, from 2011 till 2016. Since October
2016, he has commenced his PhD studies at the Institute of Immunology,
Medical Faculty, University of Duisburg-Essen, Germany. He has PhD
scholarship from DAAD (Deutscher Akademischer Austauschdienst)
(German Academic Exchange Service).
tamer_balaawi@yahoo.comThamer A Hamdan et al., Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-003