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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 70
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
P
rostaglandins (PGs) are recognized as important immune
regulators. Using human follicular dendritic cell (FDC) like cells,
we have investigated the immunoregulatory role of PGs and their
production mechanisms. We have recently reported on the positive
feedback effect of PGs, and the present study was aimed at determining
the role of ERK and p38 MAP kinases in PG-induced cyclooxygenase-2
(COX-2) expression by immunoblotting. COX-2 is the key enzyme
responsible for PG production in FDC-like cells, which produce PGE2,
PGI2, and PGF2α. An ERK inhibitor inhibited PGF2α from inducing COX-
2 whereas a p38 inhibitor prevented PGE2- and PGI2-stimulated COX-2
induction. In line with these results, PGE2 and PGI2 treatment resulted
in up-regulation of p38 phosphorylation while PGF2α stimulation led to
phosphorylation of ERK. We are currently confirming these results with
RNA interference technology. These findings suggest that ERK and
p38 play differential roles in COX-2 expression in FDC-like cells and
shed a therapeutic potential in the treatment of immune inflammatory
disorders.
Opposing role of ERK and p38 in the positive feedback production
of prostaglandins by human follicular dendritic cell like cells
Jongseon Choe and Bongjae Kwon
Kangwon National University, South Korea
Biography
Jongseon Choe had completed Ph.D. degree in immunology at Seoul
National University, Korea in 1995 and worked at Ochsner Medical
Institute (New Orleans, USA) as a research fellow. His published papers
include “In this issue” article in Journal of Immunology (180:1390-1397)
and “Highlighted article” in International Immunopharmacology (12:635-
642). As a faculty member of Kangwon National University, he is currently
interested in the productionmechanisms and inherent roles of eicosanoids
in the germinal center of peripheral lymphoid tissue.
jchoe@kangwon.ac.krJongseon Choe et al., Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-003