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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 67
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
D
ermatomyositis, a subgroup of idiopathic inflammatory myopathy,
is characterized by inflammation of muscles and skin. In Asian
cohorts, the presence of anti-melanoma differentiation-associated
gene-5 (MDA5) autoantibody in dermatomyositis patients is often
associated with rapidly progressive interstitial lung disease (RP-
ILD). Here we examined the immune system of MDA5-positive
dermatomyositis patients (n=9) and compared with healthy controls
(n=10). The percentages of Th17 and Treg cells in the peripheral
bloods fromMDA5-positive dermatomyositis patients were higher than
those from healthy controls. Furthermore, circulating proinflammatory
levels of IFNγ, IL-17, TNFα, IL-6, CCL18, and IP-10 from MDA5-positive
dermatomyositis patients were significant increase compared
with healthy controls. These data suggest that MDA5-positive
dermatomyositis patients had the dysregulated immune system and
the exacerbated inflammation response. In addition, plasma surfactant
protein D and Krebs von den Lungen-6 levels in MDA5-positive
dermatomyositis patients were markedly higher than those in healthy
controls, supporting that the presence of anti-MDA5 autoantibody in
dermatomyositis patients usually had lung fibrosis phenomena.
Dysregulated immune system in MDA5-positive
dermatomyositis patients
Shih-Hsin Chang, Ju-Pi Li and Joung-Liang Lan
China Medical University Hospital, Taiwan
Biography
Ju-Pi Li has completed her PhD from National Tsing Hua University and
Postdoctoral studies from Immunology Research Center, National Health
Research Institutes in Taiwan. She is an Assistant Research Fellow of
China Medical University Hospital. She has published about 20 papers in
reputed journals.
d888203@gmail.comJu-Pi Li et al., Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-003