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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 74
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
T
he sheephead mushroom (
Grifola frondosa
, GF) that
contains several physiologically active compounds, of which
polysaccharides, specifically β-glucans. Its efficacy as to possess
various promising bioactivities, mainly including anti-tumor and anti-
oxidation, immunomodulation, anti-hyperglycemia. This study aimed
to investigate the possible protective or ameliorative effect of GF on
obesity and anti-hyperglycemia in diabetic mice. Forty male and female
genetically diabetic mice
(BKS.Cg-+Leprdb/+Leprdb/OlaHsd) were
used and divided into five groups, 5 animals each; at the dose of 0, 75,
150, and300mg/kgBWGFextractmixedwith fedand insulin treat group.
After eight weeks of feeding, serum biochemistry, histopathological,
and immunohistochemical definding were performed. In contrast to the
control group, treat groups caused significant decreased in absolute
and relative weights of major organs, levels of insulin as well as leptin
and triglyceride in plasma demonstrated a change similar to blood
glucose with feeding of sheephead mushroom. These results suggest
that the long term
G
.
frondosa
consumption alleviates the obesity and
hyperglycemia in diabetic mice and to provide biological activities
of G. frondosa polysaccharides to support their further therapeutic
potentials.
Sheephead mushroom (
Grifola frondosa
) alleviates obesity
and hyperglycemia in db/db mice
Daeyoung Kim, Jaekweon Park and Youjin Hwang
Gachon Unversity, Republic of Korea
Biography
D. Kim graduated from the college of veterinary medicine and earned his
doctorate degree at Seoul National University, South Korea in a research
paper on the production of transgenic pigs by somatic cell nuclear transfer
in 2003. The same year, he joined the Department of Life Sciences at
Gacheon University and became a professor. He served as a school affairs
committee member, head of the student ministry, and vice chairman of
the committee on animal ethics, and lectures on developmental biology
are being conducted. Major areas of interest are diabetes, sarcopenia,
pulmonary fibrosis and tendinopathy animal model.
davekim@gachon.ac.krDaeyoung Kim et al., Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-003