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Pharmacognosy 2018 American Journal of Ethnomedicine
ISSN: 2348-9502 Page 33
April 16-17, 2018
Amsterdam, Netherlands
6th Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Statement of the Problem: Diabetic foot ulcers are one of
the major complications among diabetic patients. Wounds,
under diabetic conditions show delayed healing due to
microbial infection, generation of reactive oxygen species and
reduced blood flow. A control over the blood glucose along
with alternative therapies would be an ideal measure to treat
diabetic foot ulcers and wounds. The search for cost-effective
medication with maximum healing properties and minimal to
no side effect has led scientists to investigate plants as an
alternative source of medicinal products.
Methodology & Theoretical Orientation: This study features
the use of Syzygiummundagam bark methanol (SMBM) extract
in the treatment of wounds in streptozotocin-nicotinamide
induced diabetic rats. The extract ointment base, at 1 and 2%,
respectively, was applied to the wounded areas on the rats and
monitored for 21 days. The wound closure, epithelialization
period and histopathology of the wounds were evaluated
during the study.
Findings: Both the concentrations of the extract (1% and 2%)
healed the wounds even under diabetic conditions induced in
rats on day 21 (99.69% and 100%, respectively). The 2% SMBM
treated animals showed a higher rate of epithelialization of the
wound (15±0.49 days). The histopathology of the wounded
skin on 10th day revealed that the rats treated with SMBM
extract could initiate the healing and re-epithelialization. This
was evident from the migration of neutrophils and proliferation
of fibroblasts. On the 21st day, complete healing of the skin
could be observed in the rats treated with 2% extract which was
evident from the newly formed epidermis, collagen fibres and
fibroblast. The results compared well with those treated with
betadine (5%).
Conclusion & Significance: The results of this study will
support the use of this plant extract for diabetic healing over
the use of commercially available synthetic drugs.
Recent Publications
1. Saikumar S, Chandran R, Sajeesh T, Abrahamse H and
Parimelazhagan T (2018) Phytochemical composition,
antioxidant and anti-bacterial activity of wild edible
fruit Syzygium calophyllifolium Walp. Journal of Food
Science and Technology 55(1):341–350.
2. Chandran R, George B P, Abrahamse H and
Parimelazhagan T (2017) Therapeutic effects of
Syzygium mundagam bark methanol extracts on Type-
2 diabetic complications in rats. Biomedicine and
Pharmacotherapy 95:167–174.
3. Chandran R, Abrahamse H, Parimelazhagan T and
Gowtham D (2017) Syzygium mundagam bark
methanol extract restores skin to normal in diabetic
wounded rats. Biomedicine and Pharmacotherapy
94:781–786.
4. Chandran R, Parimelazhagan T and George B P (2017)
Anti-hyperglycemic activity of the bark methanolic
extract of Syzygium mundagam in diabetic rats.
Alexandria Journal of Medicine 53(4):317–324.
5. Chandran R, Saravanan S, Sajeesh T and
Parimelazhagan T (2016) Antidiabetic activity
of Syzygium calophyllifolium in streptozotocin-
nicotinamide induced Type-2 diabetic rats.
Biomedicine and Pharmacotherapy 82:547–554.
Biography
Rahul Chandran is currently doing Post-doctoral Research under the supervision
of Prof. Heidi Abrahamse in Laser Research Centre, Faculty of Health Sciences,
University of Johannesburg, South Africa. His research focus is on the differentia-
tion of stem cells to insulin producing cells for diabetic therapy. He has published
22 research articles in the field of Pharmacology and Nutritional Sciences in peer
reviewed international journals. He has filed patent for the novel compounds iso-
lated during Doctoral research. During his PhD in Botany, he was awarded with
DST-INSPIRE fellowship from the Ministry of Science and Technology, Govt. of In-
dia and worked as Junior and Senior Research Fellow for the period of five years.
Wound healing property of Syzygium mundagam bark methanol
extract in diabetic rats
Rahul Chandran and Heidi Abrahamse
University of Johannesburg, South Africa
Rahul Chandran et al., Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-005