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Pharmacognosy 2018
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 91
April 16-17, 2018
Amsterdam, Netherlands
6
th
Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Mohammed Z et al., Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-006
M
edicinal plants provide the best option as a safer and
more effective medication due to the presence of various
compounds. Presently, available therapeutic agents for non-
insulin-dependent diabetes mellitus such as insulin, oral
hypoglycaemics, and dietary modification all have limitations.
Chromolaena odorata
has been reported to be traditionally
used in Nigeria for the treatment of diabetes without scientific
justification. This study was carried out to investigate the
presence of antidiabetic bioactive constituents present in the
leaves of
C. odorata
and also to determine the best solvent
suitable for extracting its various phytochemical compounds.
C.
odorata
leaves extract obtained by soxhlet extraction using seven
solvents of varying polarity, were quantitatively analyzed using
standard laboratory methods for the presence of phytochemical
constituents with diabetic activity. Results obtained revealed the
presenceoftannins,saponins,flavonoids,anthraquinones,cardiac
glycosides, triterpenoids and sterols in all the solvent extracts
of the leaf sample of C. odorata. There was however, absence
of alkaloids. The aqueous solvent showed higher dissolution
and extraction of the bioactive compounds followed by ethanol,
methanol, ethyl acetate, chloroform, acetone and petroleum
ether in descending order. The results from the study could be
useful in the selection of appropriate solvents for the extraction
of pharmacologically active constituents in the formulation and
development of antidiabetic herbal drug from
C. odorata
leaves.
The presence of the various compounds could be responsible for
the antidiabetic activity of
C. odorata
, thus justifying the folkloric
use of the plant for treating diabetes.
zeedullah1@yahoo.co.ukEvaluation of phytochemical and antidiabetic components
of Chromolaena odorata L. King and Robinson (Asteraceae)
cultivated in Nigeria
Mohammed Z, Nath-Utoh E, Garba I, Abdurrahman E M
and
Abubakar A
Ahmadu Bello University, Nigeria