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Pharmacognosy 2018
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 85
April 16-17, 2018
Amsterdam, Netherlands
6
th
Edition of International Conference on
Pharmacognosy and
Medicinal Plants
B
erberis vulgaris
L. (Berberidaceae) is an evergreen plant.
The fruits of the plant are used to enhance the food taste.
Berberis L. species are effective as anti-insomnia, liver protective,
antibacterial, antifungal and anti-inflammatory, and have different
constituents such as alkaloids, flavonoids, mineral compounds
and phyto-acids. Peptic ulcer disease is one of the most common
diseases, it means disintegration of gastric or duodenal mucosa
integrity and one of the symptoms is burning epigastric pain that
is selected by food intake and exacerbated by starvation. In this
study, 24 male Wistar rats were fasted for 48 hours. Peptic ulcer
was induced by Indomethacin (50mg/kg). The rats randomlywere
divided in to four groups of six.
Berberis vulgaris
hydroalcoholic
fruits extract (BVHFE) (50, 100 mg/kg), omeprazole (40 mg/
kg) and normal saline (5 mL/kg) were administered orally to the
rats for 14 days. After five hours of the last dose, all animals
were anesthetized by ether and sacri ced. Their stomachs were
prepared to J. Score by loop and the histopatologic examination.
Both doses of BVHFE had significant effects on improvment of
ulcers in the stomachmucosa, reduced inflammation, accelerated
wound healing and BVHFE (100 mg/kg) was found to be the best.
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nafiseh.khosravi85@gmail.comHistopathological effects of hydroalcoholic extract of
Berberis vulgaris on experimental stomach peptic ulcer in rats
Nafiseh Khosravi Dehaghi
1
, Fariborz Moayer
2
and
Kiyoomars Kahvand
2
1
Alborz University of Medical Sciences, Iran
2
Islamic Azad University, Iran
Nafiseh Khosravi Dehaghi et al., Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-006