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Journal of Medical Physics and Applied Sciences
ISSN: 2574-285X
I n t e r n a t i o n a l C o n f e r e n c e o n
Nuclear Medicine &
Radiation Therapy
Nuclear Medicine & Radiation Therapy 2018
O c t o b e r 0 1 - 0 2 , 2 0 1 8
S t o c k h o l m , S w e d e n
Synthesis, quality control and biodistribution of
techneium-99m triamcinolone acetonide (
99
mTc-
TA) complex: an inflammation tracer agent
Faheem Askari Rizvi
1
, Syed Ali R Naqvi
1
and Samina Roohi
2
1
Government College University Faisalabad, Pakistan
2
Pakistan Institute of Nuclear Science and Technology, Pakistan
J. med phys & appl sci 2018, Volume: 3
DOI: 10.21767/2574-285X-C1-003
In the present study, synthesis of 99mTc-triamcinolone acetonide (
99
mTc-TA) complex and its stability using set of quality control
parameters such as ligand concentration, reducing agent concentration, pH, temperature and reaction time was assessed.
99
mTc-
TA complex was characterized in terms of percent (%) yield, stability in saline and serum using chromatographic procedures.
Radiochemically, the
99
mTc-TA complex was found quite stable in saline and serum. After 30 min of reaction, the complex showed
maximum radiochemical yield of 96.32% which decreased to 96.25% after 4 h of incubation period. In serum, the % yield of
radiochemical was remained same up to 2 h which decreased to 93.5% at 24 h time point. Normal biodistribution pattern in
Sprague Dawley rats revealed liver, stomach and kidneys as areas of high 99mTc-TA complex uptake (8.44±1.32%, 8.75±1.03%
and 12.67±1.21%, respectively) at 1 h post injection time point. Scintigraphy of
99
mTc-TA in rabbits showed similar eco as observed
in biodistribution study. Based on the promising results obtained in context of in vitro and in vivo stability and biodistribution,
99
mTc-TA complex could be further studied to identify the inflammation based diseases.
Figure 1:
A) Structure of anti-inflammatory agent triamcinolone acetonide, B) the proposed structure of 99mTc-TA complex; the
oxygen from hydroxyl and carbonyl carbon from two molecule of TA make coordination bond and present at apex of the complex
while oxygen from reduced TcO core present at pyramid of the complex.
Faheemaskaririzvi@gmail.com