nuclear-medicine-radiation-therapy-2018-posters

Page 55

Journal of Medical Physics and Applied Sciences

ISSN: 2574-285X

I n t e r n a t i o n a l C o n f e r e n c e o n

Nuclear Medicine &

Radiation Therapy

Nuclear Medicine & Radiation Therapy 2018

O c t o b e r 0 1 - 0 2 , 2 0 1 8

S t o c k h o l m , S w e d e n

ncreased use of computer simulations in treatment planning for cancer has highlighted the need for more effective methods in

modelling nuclear organisation. Current models aim to predict treatment outcomes by simulating the induction of double strand

breaks in the DNA of irradiated cells. In proton therapy, this is achieved via use of Geant-4 software, which tracks electron activity

after irradiation with a proton beam. Predictive assays can then be used to assess the value of the relative biological effectiveness

(RBE) for protons. Currently, the proton RBE value of 1.1 is taken from results in clinical practice; with proton therapy machinery

calibrated using depth dose distribution in water for beams of varying energies. It is thought that a more appropriate value could

be computed by analysing to what extent proton beams cause chromosome aberrations, a form of genomic reorganisation that

indicates damage to the cell nucleus. For this objective to be realized, the geometric organisation of the nucleus needs to be

accurately modelled so that it can be integrated with cellular irradiation simulations. This review describes and evaluates some

of the modelling approaches for chromosome territories, and aims to recommend a particular approach that research groups

involved in proton therapy can use in their work.

Considering the spatial organization of DNA

to assess proton therapy relative biological

effectiveness

Natasha Gilmour and Michael Merchant

The University of Manchester, UK

J. med phys & appl sci 2018, Volume: 3

DOI: 10.21767/2574-285X-C1-003