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Journal of Medical Physics and Applied Sciences
ISSN: 2574-285X
I n t e r n a t i o n a l C o n f e r e n c e o n
Nuclear Medicine &
Radiation Therapy
Nuclear Medicine & Radiation Therapy 2018
O c t o b e r 0 1 - 0 2 , 2 0 1 8
S t o c k h o l m , S w e d e n
I
nnuclearmedicine, the radiationchemistryprovidesefficient tools for cancer imagingusingcompounds labeledwith radionuclides
that emit gamma radiations. In my presentations, I will be explaining the radio labeling methods of two new compounds, (cancer
drugs): 5-Flurouracil (5-FU) and zoledronic acid (ZA) for tumor imaging by the scintigraphy (nuclear imaging). 5-fluorouracil is a
chemotherapeutic agent and generally used in the targeted therapy for the solid tumors, therefore, I had objective to make this
5-FU a diagnostic compounds for the colon carcinoma, a type of solid tumors, patients. The other drug, zoledronic acid is a bone
seeking bisphosphonate and has a strong affinity to bones, so the target was to do osteoscintigraphy. I have radio labeled these
two anti-cancer compounds with work horse of nuclear imaging:
99m
Tc radioisotope. For radiolabeling, we have adapted standard
reduction methods with slight modifications used for general radio labeling of radioisotopes. The different concentrations of
reducing agents has been used and also standardized for adequate radiolabeling. The chemical analysis of these compounds
also has been done prior to human studies. The previous work regarding the animal and human has been studied. Radiochemistry
of the compounds has been studied. We have conducted human studies with these compounds after taking proper safety. These
both radio pharmaceutical injected intravenous and nuclear imagings were done with the help of the SPECT system. The other
clinical and radiological data also used for the correlations. Radio-pharmacokinetics and bio-distributions have been analysis
with the help imaging data and processing software (Syngo, Molecular Imaging). The results of the human studies were very
much favorable to make these compounds potential radiopharmaceutical for the Ca Colon and bone cancer respectively. The
5-FU and ZA have provided very satisfactory data and information for to use them as for the nuclear medicine imaging.
rsonuclear@gmail.comRadiolabeling and scintigraphic evaluation of
Tc-99m labeled 5-fluorouracil and zoledronic
acid for tumor imaging
Shekhawat Kan
1, 2
1
Bhagwan Mahaveer Cancer Hospital and research Centre, India
2
Jaipur National University, India
J. med phys & appl sci 2018, Volume: 3
DOI: 10.21767/2574-285X-C1-003