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Journal of Medical Physics and Applied Sciences
ISSN: 2574-285X
I n t e r n a t i o n a l C o n f e r e n c e o n
Nuclear Medicine &
Radiation Therapy
Nuclear Medicine & Radiation Therapy 2018
O c t o b e r 0 1 - 0 2 , 2 0 1 8
S t o c k h o l m , S w e d e n
Aim:
To study the optimal dose and optimal time of human skeletal imaging using 99mTc-zoledronic acid (Tc-99m-ZA)
Materials:
30 consecutive patients referred to the nuclear medicine department for bone scan were enrolled for the study after
a valid consent.
Methods:
The patients were divided into subgroups as described. Tc-99m-ZA was prepared as per the standardized protocol.
Patients were divided into 3 groups of 10 each. Group A1 was injected intravenously 5 mCi of tracer, Group A2 was injected 10
mCi of tracer and Group A3 was injected 15 mCi of tracer. The patients were asked to maintain good hydration. In each group,
the images were acquired at 1, 2, 2.5 hour(s) after tracer injection in all the patient groups in whole body mode using low energy
high resolution (LEHR) collimator. After completion of the study, the images were interpreted independently by two observers for
the presence of adequate tracer uptake in the skeleton and also for optimal bone to background ratio. Their findings were then
compared and when differences were there the decision was finalized by consensus.
Findings:
The skeletal images obtained using Tc-99m-ZA were quite similar to those obtained with
99
mTc-methyl diphosphonate
(Tc-99m-MDP). The optimal dose for skeletal scintigraphy using Tc-99m-ZA was 15 mCi. The optimal timing post tracer injection
was 2 hours.
Conclusion:
The images obtained with Tc-99m-ZA are very encouraging. Their revelation of human skeleton matches with that is
achieved with established agent Tc-MDP. However, further studies with a large cohort of patients are warranted for clinical use of
Tc-99m-ZA and establish its performance
vis-a-vis
Tc-99m-MDP.
rsonuclear@gmail.comFirst human studies experience for dose and
time optimization by 99mTc-zoledronic acid for
osteoscintigraphy
Shekhawat Kan
1,2
1
Bhagwan Mahaveer Cancer Hospital and research Centre, India
2
Jaipur National University, India
J. med phys & appl sci 2018, Volume: 3
DOI: 10.21767/2574-285X-C1-003