20 / 23
Page 64
Journal of Medical Physics and Applied Sciences
ISSN: 2574-285X
I n t e r n a t i o n a l C o n f e r e n c e o n
Nuclear Medicine &
Radiation Therapy
Nuclear Medicine & Radiation Therapy 2018
O c t o b e r 0 1 - 0 2 , 2 0 1 8
S t o c k h o l m , S w e d e n
W
e present the development and characterization of a [
99
mTc] tricarbonyl urea. Labelling with high yield and radiochemical
purity was achieved through the formation of a [
99
mTc] tricarbonyl urea radiotracer. The radiolabeled compound was
stable and exhibited plasma protein binding (approximately 40%). The logarithm of the partition coefficient (log p) value of
[
99
mTc] tricarbonyl urea was -2.55±0.17 (hydrophilic). Bio-distribution studies in normal mice confirmed the suitability of [
99
mTc]
tricarbonyl urea as a novel tracer to image kidneys. [
99
mTc] tricarbonyl urea could be considered a new selective radiotracer for
kidneys imaging.
drsanad74@gmail.comSynthesis, labelling and preliminary
bioevaluation of 99mTc-urea as a potential
kidneys imaging agent
M H Sanad
1
and Dina H Salama
2
1
Egyptian Atomic Energy Authority (EAEA)-HLWMC, Egypt
2
National Center for Radiation Research and Technology-AEA, Egypt
J. med phys & appl sci 2018, Volume: 3
DOI: 10.21767/2574-285X-C1-003