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Volume 4

Nano Research & Applications

ISSN: 2471-9838

Page 98

JOINT EVENT

August 16-18, 2018 | Dublin, Ireland

Edition of International Conference on

Nanopharmaceutics and Advanced Drug Delivery

Nano Congress for

Future Advancements

Nano Congress 2018

Nano Drug Delivery 2018

August 16-18, 2018

Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C3-015

UV spectro photometric method development & validation of duloxetine hydrochloride in bulk

and solid dosage forms

P. Sailaja Kshatriya

and A.Ramanakumar

A.M.Reddy Memorial College of Pharmacy, India

Duloxetine Hydrochloride:

Duloxetine is a serotonin-nor epinephrine reuptake inhibitor. Effective for major depressive

disorder and in generalized anxiety disorder. Drug analysis plays an important role in the estimation of the purity and quality

of drugs, which are used in pharmaceutical formulations. In order to reduce the load and confusion to the patients, the disease

is managed with several drugs in individual doses. Standard analytical procedures for these drugs or formulations may not be

available, or the original methods are cumbersome, time consuming. Hence, it is important to develop methods such that, they

are widely available and in common use in control laboratories.

Linearity:

The linearity study was carried out for DLX in zero order spectrum at the above said wavelength. The calibration

curves were obtained by plotting absorbance versus concentration of the standard solution

Accuracy:

Accuracy of the method was established by recovery studies by external standard addition method. The known

amount of standard was added at three different levels to the preanalysed sample solution, each determination was performed

in replicate. The amount recovered and the percentage recovered was calculated.