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Volume 4
Nano Research & Applications
ISSN: 2471-9838
Page 90
JOINT EVENT
August 16-18, 2018 | Dublin, Ireland
&
12
th
Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25
th
Nano Congress for
Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-015
Next generation C
60
enabled antibiotics
Martin Quirke
1, 2
1
Dublin Institute of Technology, Ireland
2
FOCAS Institute - DIT, Ireland
T
he objective of my research is to design, synthesize and tailor a nanoparticle-antibiotic conjugate capable of a multi-
targeted approach tomulti drug resistant (MDR) pathogenic bacterial infections, such as C
60
–Ampicillin. Post-synthesis the
mechanisms of interaction between the conjugate and the bacteria will be elucidated, to allow for refinement and optimisation of
the multi-targeted approach. This work will develop new methodologies and standards for testing the antimicrobial properties
of novel nanomaterials. Current antimicrobial agents such as ampicillin and streptomycin which have worked effectively for
decades are no longer a viable way of treating bacterial infections due to the resistance they are continuously developing and
passing onto the next generation. It is imperative that a new strategy is developed to deal with this treat as a current World
Health Organization study in 2014 estimated 10 million deaths per year worldwide with this projection only to increase.
Bacteria have developed resistance to ampicillin via efflux pumps, reduced affinity, enzyme degradation and target alteration.
It is hoped these resistive traits can be attacked by the C
60
–AMP complex which offered a reduced affect when tested against
clinical strains of
E.coli
. The complex has been characterized extensively with, DLS, Zeta potential, UV/Vis spectra, IR spectra
and Raman.
martin.quirke86@gmail.com