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Volume 4
Nano Research & Applications
ISSN: 2471-9838
Page 92
JOINT EVENT
August 16-18, 2018 | Dublin, Ireland
&
12
th
Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25
th
Nano Congress for
Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-015
Fluorescent and T1 MRI active multilayer nanoparticle for imaging and targeting cellular delivery
Oara Neumann
Rice University, USA
M
ultifunctional plasmonic nanostructures have enormous potential in the treatment of solid tumors, however, tracking
particles with drug cargo and triggering the release of the cargo in mapped tumors is still impossible. To overcome this
challenge we have developed an MRI and fluorescent active nanostructure nanomatryoshka. This new nanostructure with IR
plasmonic signatures is composed of a 50 nm Au core surrounded by dye molecules and Gd(III)-DOTA chelate doped SiO2
inner-shell and an outer Au shell. The experimental results demonstrates an enhanced T1 relaxation (r1~24 mM-1 s-1 at 4.7
T) compared to the clinical Gd(III)-DOTA chelating agents (r1~4 mM-1 s-1). Further, this design preserves the fluorescence
signal (65%) after 24 hours of exposure, leading to enahanced fluorescence photostability (23x).This dual-imaging functionality
nanosystem increases MRI sensitivity by concentrating Gd(III) ions into the Gd-NMs, reduces the potential toxicity of Gd(III)
ions and dye molecules by preventing their release
in vivo
through the outer Au shell protection, and the terminal gold layer
surface can then be functionalized to increase cellular uptake, circulation time, or thermal drug-release properties.
on4166@rice.edu