nano-congress-nano-drug-delivery-2018-posters

Volume 4

Nano Research & Applications

ISSN: 2471-9838

Page 94

JOINT EVENT

August 16-18, 2018 | Dublin, Ireland

Edition of International Conference on

Nanopharmaceutics and Advanced Drug Delivery

Nano Congress for

Future Advancements

Nano Congress 2018

Nano Drug Delivery 2018

August 16-18, 2018

Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C3-015

Confined nanoscale geometries to enhance sensitivity of plasmonic immunoassays

Rishabh Rastogi

Luxembourg Institute of Science and Technology, Luxembourg

ensitive transduction of bio-molecular binding events on chip carries profound implications to the outcome of a range

of biological sensors. This includes biosensors that address both research as well as diagnostic questions of clinical

relevance, e.g. profiling of biomarkers, protein expression analysis, drug or toxicity screening and drug-efficacy monitoring.

Nanostructured biosensors constitute a promising advance in this direction owing to their ability in catering to better

sensitivity, response times, and miniaturization. Plasmonic sensors are particularly interesting among nano-biosensors as they

exploit light matter interactions in the nanoscale to transduce bio-recognition events with high sensitivity and miniaturized

measurement footprints. Examples of plasmonic sensors include localized surface plasmon resonance spectroscopy (LSPR),

surface enhanced Raman spectroscopy (SERS) and metal-enhanced fluorescence (MEF). The performance of the plasmonic

sensors critically relies on ability to engineer nanoscale geometric attributes at length scales that typically overlap with the

size of small proteins. Such geometries invariably introduce constraints on the molecular binding response, thus altering the

interaction outcomes, viz. density and kinetics of adsorption, molecular orientations, in a manner that would impact the

resulting optical response. A careful engineering of the nanoscale geometries can simultaneously take advantage of EM field

enhancements together with molecular interaction within nanoscale geometries. To this end, this project aims at an engineered

nanoscale interface with geometry tailored to simultaneously favour molecular adsorption and plasmonic enhancements for

application to plasmonic sensors based on surface-enhanced Raman and fluorescence spectroscopies.