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Medchem & Toxicology 2018
Page 88
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
I
ndeed, investigations using quantitative structure activity relationships (QSAR) are quite essential for modern chemistry and
biochemistry. For qualified scientists such investigations having additional advantages as giving the background interpretations
for the fine effect of each predicted descriptor. Among these of very important applications is that the exploiting of QSAR in drug
design and discovery. Recently, Kumar and his co-workers have addressed 32 derivatives of 4-(1-aryl-2-oxo-1,2-dihydro-indol-
3-ylideneamino)-N-substituted benzene sulphonamides [Arabian Journal of Chemistry (2014) 7, 396-408]. It seems interesting
to investigate theoretically the main factors that influence the activity of these synthesised compounds for antimicrobial and
anticancer therapy. This could lead to have an important hint that may be quite helpful for predicting and developing new
molecules that could be more effective in those issues. The results showed that there is a good correlation between topological
properties of molecules with their antimicrobial activity. For example, the Balaban index that depending on the number of edges
for molecules plays a major role which gives an individual correlation coefficient of +0.714. In a similar manner, the cluster count
and polar surface area as also belonging to topological properties give a good correlation. On the other hand, the results indicate
that there is no any significant correlation between all properties with anticancer activity. In other words, there is no connection
between the parameters that affecting antimicrobial activity with that of anticancer. Therefore, extensive efforts must be paid in
order to find the suitable parameters that could help for predicting new anticancer compounds.
rakhalil64@yahoo.comTheoretical investigations for some N-substitute
benzene sulphonamides for acting as
antimicrobial and anticancer therapy
Rabah A Khalil and Shayma'a Hashim
University of Mosul, Mosul, Iraq
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-009