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Medchem & Toxicology 2018
Page 90
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
F
resh oyster white translucent sap obtained from the tender unopened inflorescence of coconut trees (
Cocos nucifera
) is
identified to have great health benefits. Drug induced nephrotoxicity is one of the major causes of renal damage in present
generation. As a therapeutic agent, gentamicin imparts direct toxicity to kidney, resulting in acute tubular necrosis, glomerular and
tubulointerstitial injury, haemodynamically mediated damage and obstructive nephropathy. There exists an increasing demand for
safe and natural agents for the treatment and/or prevention of chronic nephrotoxicity and pathogenesis of kidney diseases. Our
study shows the nephro protective/curing effect of a novel powder formulation of micronutrient enriched, unfermented coconut
flower sap (CSP). The study was performed on adult male Wistar rats. The animals were grouped into three and treated separately
with vehicle, gentamicin and gentamicin+CSP for 16 days. Initially, gentamicin treatment significantly (p<0.05) reduced the levels
of antioxidant enzymes (SOD, CAT, GPx) and GSH and increased (p<0.05) the levels of creatinine, uric acid, urea, inflammatory
markers (nitrite, IL-6, TNF- α, iNOS) and lipid peroxidation. Supplementation of coconut flower sap powder showed significant
(p<0.05) reversal of all these biochemical parameters indicating an effective inhibition of the pathogenesis of nephrotoxicity and
kidney disease
biochemistrystcp@gmail.com sivatheertha@gmail.comAmelioration of renal inflammation, oxidative
stress and necrosis underlies the protective
effect of unopened coconut inflorescence sap
powder in gentamicin-induced nephrotoxicity
Ratheesh M
1
, Svenia P Jose
1
, Sandya S
2
and Krishnakumar I M
3
1
St.Thomas College, Palai, Kerala, India
2
Indian Institute of Science, Bangalore, India
3
Akay Flavours & Aromatics Pvt Ltd, Cochin, Kerala, India
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-009