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Medchem & Toxicology 2018
Page 93
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Background:
Embelia schimperi
is among medicinal Mvrsinaceae plants found in Ethiopia which find a wide range of application
in ethno-pharmacology as antimicrobials and antihelmentic. It has been used for the treatment of intestinal parasites especially
tapeworm infestations for centuries in Ethiopia. This study has therefore evaluated the efficacy and phytochemical analysis of
E.
schimperi
thereby generating relevant preclinical information.
Methods:
The fruit berries of
E. schimperi
were extractedwith coldmethanol, n-hexane, ethanol, petroleumether. The antihelmentic
activity was evaluated on the earthworm
Pheretima posthuma
collected due to its anatomical and physiological resemblance
with the intestinal round worm parasites of human. Antibacterial activity was carried out with the pure compounds against
Staphylococcus aureus
and
Salmonella typhi
.
Results:
The paralysis causing concentration within 30 minutes of the crude extracts and Albendazole were 50 mg/ml and 25 mg/
ml respectively. The crude extracts showed nematicidal activity against the earth worms whereas the nematocidal concentration
required within 30 minute for the crude extracts and Albendazole were 100 mg/ml and 25 mg/ml. The crude extracts showed
nearly similar activities against all the tested bacteria in the study. From zone inhibition diameters of compounds
Embelia
schimperi
methanol and ethanol extract were compared on S typhi and
S. aureus
, both compounds were showed activity on
S.
aureus
nearly in similar way. These compounds were reasonably active against S typhi and
S. aureus
it makes an appropriate
candidate for further investigation in control of these multi-drug resistant bacteria.
Conclusion:
Antibacterial activities vary with the test organisms, plant material and the solvents used. Thus, the result ascertains
the value of plant used in the study could be of considerable interest to the development of new antimicrobial drugs.
tesfalem2002@gmail.comPhytochemical and antimicrobial activity of
bioactive compound extracted from Embelia
schimperi Vatke against human pathogens
Tesfaye Wolde, Tamru Demsis, Shemsu Ligani and Tesfaye
Hailemariam
Wolkite University, Wolkite, Ethiopia
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-009