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Pharmacognosy 2019
March 11-12, 2019
London, UK
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 53
Pharmacognosy and
Medicinal Plants
7
th
Edition of International Conference on
Am J Ethnomed 2019, Volume 6
DOI: 10.21767/2348-9502-C1-009
Enzyme inhibitory activities of
Nymphaea alba
fruit extracts
Mihaela Cudălbeanu, Ioana O Ghinea, Anna Cazanevscaia, Bianca
Furdui
and
Rodica M Dinica
Universitatea “Dunărea de Jos” din Galați, Romania
Statement of the Problem:
In the developing countries
the diabetes and also the hyperuricemia can cause many
problems for people’s health and has shown an increasing
trend among the urban population. The studies published
before reported that the alcoholic extracts of
Nymphaea
alba
from the Danube Delta Biosphere Reserve have
bioactive compounds like polyphenols and flavonoids.
The
Nymphaea alba
fruit extracts were investigated
further to determine their therapeutic potential to inhibit
key enzymes involved in carbohydrate metabolism or in
the catabolism of purines.
Methodology & Theoretical Orientation:
The evaluation
of enzyme inhibitory activity of alcoholic extracts of
Nymphaea alba
fruits was carried out against α-amylase
and xanthine oxidase. It is known that polyphenols readily
complex with protein and as a result, there is an inhibition
of enzyme activity. Enzyme inhibitory activities of the
extracts from
Nymphaea alba
fruits were assayed in vitro.
Findings:
The results indicate that the evaluated alcoholic
extracts were exerted higher inhibitory activity against
both α-amylase and xanthine oxidase enzymes, having
the highest xanthine oxidase inhibitory activity (IC50 =
160 µg/mL), and also α-amylase having highest inhibitory
activity (IC50 = 4 mg/mL).
Conclusion & Significance:
The obtained results suggest
that the
Nymphaea alba
fruit extracts have the major
components inhibiting the α-amylase and xanthine
oxidase activity in vitro.