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Pharmacognosy 2019
March 11-12, 2019
London, UK
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 56
Pharmacognosy and
Medicinal Plants
7
th
Edition of International Conference on
Am J Ethnomed 2019, Volume 6
DOI: 10.21767/2348-9502-C1-009
Abortive effect of the aqueous extract of germinated seeds
of
Trigonella foenum graecum
L. in mice
Oufquir S
1
, Ait Laaradia M
1
, Chait A
1
, Sokar Z
1
and
Aboufatima R
2
1
Cadi Ayyad University, Morocco
2
Université Sultan Moulay Slimane, Morocco
T
rigonella foenum graecum
L. is one of the oldest
traditional medicinal plants. Fenugreek belongs to the
family of Fabaceae and is used as an herb (dried or fresh
leaves), spice (seeds), vegetable (fresh leaves). This
study was undertaken to test the side effect of fenugreek
(
Trigonella foenum graecum
L.) germinated in pregnant
female albino mice, fetal development and evaluation of
locomotive development.
Material & Methods:
A freeze dried aqueous extract of
sprouted fenugreek seeds are administered to mated
female mice throughout pregnancy at doses of 200,
500, 800, 1000 mg/kg/day. Females were examined for
parameters of reproductive performance. The fetuses
havebeenweighedandtheirbehaviorisevaluated.Ahigh-
performance liquid chromatography (HPLC) technique
was used to identify the major phenolic compounds in
the aqueous extract of germinated seeds of Fenugreek.
Results:
In pregnant mice, there were no obvious
symptoms of toxicity, deaths related to the lyophilized
aqueous extract of sprouted fenugreek seeds. But we
noted the presence of increased number of abortions in
treated mice compared to controls. The main phenolic
compounds identified in the lyophilized extract of
germinated fenugreek seeds were gallic acid, caffeic
acid, syringic acid, tyrosol, and rutin. The germinated
seeds of fenugreek showed that their aqueous extract
had an antioxidant effect.
Conclusions:
This study is the first study showing the
abortive effect of the aqueous extract of germinated
Trigonella foenum-graecum
seeds. Our finding suggests
that prenatal mouse exposure to high doses of lyophilized
aqueous extract of germinated fenugreek seeds may
lead to toxic effects on mouse reproduction.