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Pharmacognosy 2018
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 107
April 16-17, 2018
Amsterdam, Netherlands
6
th
Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-006
T
his study investigated the effects of different celery
(Apium graveolens
) seed extracts on blood pressure (BP)
in normotensive and deoxycorticosterone acetate–induced
hypertensive rats. The hexanic, methanolic, and aqueous-
ethanolic extracts were administered intraperitoneally and their
effects on BP and heart rate (HR) were evaluated in comparison
with spirnolactone as a diuretic and positive control. Also,
the amount of n-butylphthalide (NBP), as an antihypertensive
constituent, in each extract was determined by HPLC. The results
indicated that all extracts decreased BP and increased the HR
in hypertensive rats, but had no effect on normotensive rats.
The data showed that administration of 300mg/kg of hexanic,
methanolic, and aqueous-ethanolic (20/80, v/v) extracts of the
celery seed caused 38, 24, and 23mmHg reduction in BP and 60,
25, and 27 beats per minute increase in the HR, respectively. Also,
the HPLC analysis data revealed that the content of NBP in the
hexanic extract was 3.7 and 4 times greater than methanolic and
aqueous-ethanolic extracts. It can be concluded that celery seed
extracts have antihypertensive properties, which appears to be
attributable to the actions of its active hydrophobic constitutes
such as NBP and can be considered as an antihypertensive agent
in chronic treatment of elevated BP.
hassanpour.maryam100@yahoo.comAntihypertensive effect of celery seed on rat blood pressure in
chronic administration
Maryam Hassanpour Moghadam, Mohsen Imenshahidi
and
Seyed Ahmad Mohajeri
Mashhad University of Medical Sciences, Iran