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conferenceseries
.com
Volume 3, Issue 3 (Suppl)
J Obes Eat Disord
ISSN: 2471-8203
Obesity Medicine 2017
October 30-31, 2017
October 30-31, 2017 Bangkok, Thailand
15
th
International Conference on
Obesity Medicine
Retrospective study on the efficacy of antiretroviral treatment after bariatric surgery
Souama Oualid, Pastijn Els, Kappessidou Panayota and Fils Jean-François
France
Background:
Effective antiretroviral treatment offers HIV patients a normal life expectancy. However, as in the general
population, obesity is a recurrent problem in HIV patients, partly due to lipid disorders caused by antiretroviral therapy.
Bariatric surgery may be an option for these patients when diet and exercise are not sufficient, but its safety has not been fully
tested in these patients.
Method:
This was a mono-centric retrospective study (Saint-Pierre Hospital, Brussels, Belgium). We compared 14 obese HIV
affected women (G1) after bariatric surgery, with 45 obese women HIV (G2). A primary outcome was cd4, cd8, HIV viral load
and secondary factors were lipid metabolism, phosphor-calcic metabolism and renal function.
Results:
Patients in Group-1 (G1) had an average age of 46.07 years and a BMI of 44.11 kg/m2. After performing sets of paired
comparisons, testing differences before and after surgery by means of paired T-tests and paired Wilcoxon signed rank tests,
we observed stability in count cd4, cd8 and HIV viral load, with cd4-before 762±380, after 648±399 with p-value 0.33; cd8-
before 737±466, after 828±306 with p-value 0.47 and HIV viral load was 0 before and after surgery, whereas phosphor-calcic
metabolism, renal function and lipid metabolismwere stable. We have compared (G1) to (G2)-propensity score was performed;
we applied a Bonferroni correction for multiple comparison. No differences were found between cd4 count, cd8 count and
viral load before and after surgery; count cd4: 762±380 (G1), 648±399 (G2) with p-value 0.33; cd8: 737±466 (G1), 828±306
(G2) with p=0.47; HIV viral load 0 (G1), 5.79±42 (G2) with p=0.21. Secondary outcome was, no differences were observed in
calcium: 2.24 moles/L±0.12 (G1) vs. 2.28±0.12 (G2), p=0.28; phosphorus: 1.09 moles/l±0.15(G1) vs. 1.16±0.13(G2), p=0.133;
cholesterol T: 186.43 mg±42.24 (G1) vs. 166.92±19.47 (G), p=0.078; triglyceride: 95 mg/L±47 (G1) vs. 124±28 (G2), p=0.009.
Fg is the only variable significantly differing in the two groups under study, with a higher level of Fg observed the with surgery’
group (means=93.79, SD=12.77), compared to the no-surgery group (means=81.36, SD=12.30, adj. P<0.001).
Conclusions:
Bariatric surgery can be a safe option for the treatment of obesity in obese HIV patients-stability in CD4, CD8
counts and in viral load in HIV affected patients was noted, as well as improvement in glomerular filtration. We found no
consequences on phosphor-calcic and lipid metabolism.
michaelange1@yahoo.frJ Obes Eat Disord 2017, 3:3
DOI: 10.21767/2471-8203-C1-006