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conferenceseries
.com
Volume 3, Issue 3 (Suppl)
J Obes Eat Disord
ISSN: 2471-8203
Obesity Medicine 2017
October 30-31, 2017
October 30-31, 2017 Bangkok, Thailand
15
th
International Conference on
Obesity Medicine
Inhibitory effects of 4-(4-methylbenzamino) benzoate on adipocyte differentiation
Sang Yoon Choi
Korea Food Research Institute, South Korea
A
lthough some anti-obesity drugs are currently available, such as orlistat, sibutramine or sertraline, several side effects
have been reported. Thus, studies are being conducted on compounds with anti-obesity effects to replace these drugs. In
this study, the potent suppression of adipocyte differentiation by resveratrol derivative, 4-(4-methylbenzamino) benzoate, was
discovered during the search for new anti-obesity compounds. 4-(4-methylbenzamino) benzoate was observed to suppress
adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μMwithout cytotoxicity. In addition, 4-(4-methylbenzamino) benzoate
reduced the cellular expression of fatty acid synthase in a concentration-dependent manner, as well as suppressing PPAR-
gamma activity, which controls fatty acid storage and glucose metabolism. Based on these results, 4-(4-methylbenzamino)
benzoate shows potential as an anti-obesity material.
sychoi@kfri.re.krJ Obes Eat Disord 2017, 3:3
DOI: 10.21767/2471-8203-C1-006