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conferenceseries
.com
Volume 3, Issue 3 (Suppl)
J Obes Eat Disord
ISSN: 2471-8203
Obesity Medicine 2017
October 30-31, 2017
October 30-31, 2017 Bangkok, Thailand
15
th
International Conference on
Obesity Medicine
Anti-adipogenic effects on 3T3-L1 pre-adipocytes from functional plant
Pinus densiflora
Sieb. et Zucc. needles
Woong Kim, Jaeyoung Park, Cheolwoo Park, Wonjin Kim and Hyeonsook Cheong
Chosun University, South Korea
O
besity is a common disease in worldwide and considered a significant risk factor causing various complications.
Pinus
densiflora
Sieb. et Zucc. contains several natural compounds that have various biological activities. However, the health
beneficial effects of these compounds have rarely been reported. This study is to evaluate the inhibitory effect of pine needle
extract powder (PNEP) on adipocyte differentiation in 3T3-L1 pre-adipocytes. The level of adipogenesis in the 3T3-L1 cells
was measured by oil red O staining. As a result of Oil Red O staining, PNEP significantly inhibited adipocyte differentiation
by more than 55% in 3T3-L1 pre-adipocytes in a dose-dependent manner. Furthermore, we have confirmed PNEP inhibited
adipocyte differentiation by suppressing the expression of the adipogenic transcription factors, fatty acid binding protein (aP2)
and sterol regulatory element binding transcription factor-1(SREBP1c) using real-time PCR analysis. These results show that
PNEP inhibits adipogenesis by suppressing the expression of adipogenic transcription factors.
gadak2@naver.comJ Obes Eat Disord 2017, 3:3
DOI: 10.21767/2471-8203-C1-006