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NanoMat 2018
Nano Research & Applications
ISSN: 2471-9838
Page 60
April 26-27, 2018
Rome, Italy
17
th
Edition of International Conference on
Emerging Trends in
Materials Science and
Nanotechnology
N
eutron capture therapy (NCT) is a suggested treatment
for cancer. Species with large amounts of boron-10 or
gadolinium-157 are required for an effective NCT. Gadolinium-
containing nanoparticles might also be useful in MRI imaging,
thus leading to theranostic agents. Dopamine-modified boron
nanoparticles (BNPs) were prepared by ligand exchange on the
surface of hydrophobic BNPs formed by ball milling. The boron
core-silica shell nanoparticles were prepared by first performing
a hydrosilylation reaction to convert the double bonds of the
hydrophobic BNP ligands into trialcoxysilane moieties, followed
by a sol-gel reaction to form the silica shell. The latter imparts
hydrophilicity to theboronnanoparticleandprovidesasurface that
can be further modified with various functionalities for targeted
delivery. Furthermore, silica encapsulation results in particles
that are uniform in shape and size, and are easy to manipulate.
Silica nanoparticles (SNPs) grafted with carborane containing
polymer brushes were prepared by modifying the silica surface
with initiator moieties, followed by surface-initiated atom transfer
radical polymerization of reactive monomers. After the formation
of the polymer brushes, they are treated with carboranyl alcohols
or acids, resulting in an almost complete modification of the
polymer side-chains with the carboranyl moieties. Finally, silica
nanoparticles were prepared with internal functional groups and
microporosity, suitable for the incorporation of modalities for both
MRI imaging and cancer treatment by neutron capture therapy
using boron-10 and gadolinium-157 nuclei. These modalities
were incorporated by preparing ORMOSIL particles with reactive
functional groups throughout the nanoparticle body, followed by
their conversion into the metal chelating and boron-containing
moieties inside the nanoparticles.
Recent Publications
1. Brozek E M, Washton N M, Mueller K T and Zharov
(2017) Silsesquioxane particles with internal
functional groups. Journal of Nanoparticles Research
19:85-97.
2. Dubey R, Kushal S, Levin MD, Mollard A, Oh P, Schnitzer
J E, Zharov I and Olenyuk B Z (2015) Tumor targeting,
trifunctional dendritic wedge. Bioconjugate Chemistry
26:78-89.
3. Brozek E M, Mollard A H and Zharov I (2014) Silica
nanoparticles carrying boron-containing polymer
brushes. Journal of Nanoparticle Research 16:2407-
2412.
4. Gao Z and Zharov I (2014) Tannic acid-templated
mesoporous silica nanoparticles with large pores.
Chemistry of Materials 26:2030-2037.
5. Yushkova E A, Ignacio-de Leon P A, Khabibullin A,
Stoikov I I and Zharov I (2013) Silica nanoparticles
surface-modified with thiacalixarenes selectively
adsorb oligonucleotides and proteins. Journal of
Nanoparticle Research 15:1-9.
Biography
Ilya Zharov is an Associate Professor at the Chemistry Department, Univer-
sity of Utah. He obtained his BS degree in 1990 from Chelyabinsk State Uni-
versity; MS in 1994 from the Technion; and PhD in 2000 from the University
of Colorado, Boulder. In 2000-2003, he was a Beckman Postdoctoral Fellow
at the Beckman Institute for Advanced Science and Technology, University
of Illinois at Urbana-Champaign. His research focuses on novel nanoporous
materials, ion conductive membranes, and on theranostic agents. Among
his awards are Camille and Henry Dreyfus Foundation New Faculty Award
and the National Science Foundation CAREER Award. He was named an
Emerging Investigator by the
Chemical Communications
in 2011 and serves
on the Editorial Board of
Current Smart Materials.
i.zharov@utah.eduBoron and gadolinium rich nanoparticles for neutron capture
therapy of cancer
Ilya Zharov and Yulia Yegeris
University of Utah, USA
Ilya Zharov et al., Nano Res Appl, Volume:4
DOI: 10.21767/2471-9838-C1-008