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Journal of Transmitted Diseases and Immunity
ISSN: 2573-0320 Page 85
Volume 4
May 10-11, 2018
Frankfurt, Germany
Immunology Research 2018
Tissue Science 2018
JOINT EVENT
2 2 n d E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology and
Evolution of Infectious Diseases
&
1 2 t h E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Tissue Engineering and
Regenerative Medicine
Over the last decade the field of cancer biology has gained
considerable data on genomic heterogeneity. This situation
creates challenges and possibly opportunities for cancer
treatment. The evolution of the tumor at all stages also requires
the growing malignancy to confront and avoid the immune
system. What we describe here is the interaction of two immune
phenomena that work together to change the characteristics of
the tumor, i.e., antigenic competition and immunoediting. These
two systems are mutually functional and their interaction is
capable of altering the characteristics of the tumor for protection
and survival in an immune competent host as well as restricting
the diversity of the tumor clones. Therefore, the final outcome
of these interactions can also become the key to the backdoor
into the castle. Through an additional immune manipulation,
autologous tumor cell immunization, we can achieve prevention
of disease recurrence after surgical resection and by analyzing
induced human monoclonal antibodies to the neoantigens,
gain in site into the restriction of diversity of the mutant clones.
These findings may also open the door for a pathway to immune
prevention of cancer.
A key to the backdoor into the castle: the clinical
ramifications of immunoediting driven by antigenic competition
Michael G Hanna and Jason David Howard
Vaccinogen Inc., Baltimore, USA
J Transm Dis Immun 2018, Volume 2
DOI: 10.21767/2471-8084-C1-003