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academies
August 17-18, 2017 | Toronto, Canada
ANNUAL BIOTECHNOLOGY CONGRESS
Ann Biol Sci, 2017
ISSN: 2348-1927
T
his lecture will review how biomaterials and components
of the extracellular matrix, i.e. structural proteins and
growth factors, affect the osteogenic potential of human
adipose-derived mesenchymal stromal cells (ASC). Examples
of bone formation by various human adipose derived cells-
based engineered matrix/tissue, via either intramembranous
or endochondral ossification will be presented. The lecture
will then present the development of an advanced therapy
medicinal product (ATMP) based on an intraoperative use
of the stromal vascular fraction (SVF) of human adipose,
containing mesenchymal and endothelial cells, to support
bone repair with tissue harvest, cell isolation, seeding onto
scaffolding material and implantation within 3-4 hours. A
translation of this concept into a first-in-man clinical trial,
demonstrating safety, feasibility and providing proof-of-
principle of the biological functionality (i.e., bone formation)
of the implanted graft will be presented. Another clinical
case based on the use of such ATMP for mandibular bone
regeneration will be shown.
e:
arnaud.scherberich@usb.chAdipose-derived cells for clinical bone regeneration: a concept in motion
Arnaud Scherberich
University of Basel, Switzerland
Ann Biol Sci, 2017, 5:3
DOI: 10.21767/2348-1927-C1-003