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Page 54
allied
academies
August 17-18, 2017 | Toronto, Canada
ANNUAL BIOTECHNOLOGY CONGRESS
Ann Biol Sci, 2017
ISSN: 2348-1927
A
ntibody phage display is a key
in vitro
technology to
generate human antibodies. In this presentation, our
pipeline for the development of human and human-like
antibodies for diagnostics and therapy will be outlined. The
development of human and macaque antibodies against
category A and B (according to CDC) classified viruses and
toxins using phage display will be presented. Detailed
examples will be given for diagnostic and neutralization of
Venezuelan equine encephalitis virus
(VEEV),
Western equine
encephalitis virus
(WEEV), Marburg virus and botulinum
toxins (EU FP7 Antibot ABE consortium). In addition,
the germline humanization of the anti-botulinum toxin
antibodies will be outlined.
e:
m.hust@tu-bs.deDeveloping human and human-like antibodies for biodefense
Michael Hust
Technische Universität Braunschweig, Germany
Ann Biol Sci, 2017, 5:3
DOI: 10.21767/2348-1927-C1-003