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Volume 3, Issue 2
Insights in Analytical Electrochemistry
ISSN: 2470-9867
Analytical Chemistry-Formulation 2017
August 28-30, 2017
Page 20
8
th
Annual Congress on
&
14
th
International Conference and Exhibition on
August 28-30, 2017 Brussels, Belgium
Analytical and Bioanalytical Techniques
Pharmaceutical Formulations
TiO
2
based nanoparticles as solid support for chemiluminescence detection: A range of analytical
applications
Entesar Al-Hetlani, Mohmaed A
and
Metwally M
Kuwait University, Kuwait
T
his work describes a novel approach for analytes detection using Ru(bpy)
3
2+
-Ce(IV) chemiluminescence (CL). Herein,
we report the synthesis, characterization and application of a new type of hybrid nanoparticles (NPs). Mesoporous TiO
2
-
Ru(bpy)
3
2+
NPs were prepared using a modified sol-gel method by incorporating Ru(bpy)
3
2+
into the initial reaction mixture at
various concentrations. The resultant bright orange precipitate was characterized via: TEM, N
2
sorptometry, ICP-OES, Raman
and UV-Vis techniques. For comparison purposes, the concentration of Ru(bpy)
3
2+
incorporated in the NPs was quantified
and compared to the same concentration of Ru(bpy)
3
2+
in solution in terms of the CL response. The results showed this type
of hybrid material exhibited higher CL signal compared to the liquid phase due to the enlarged surface area of the TiO
2
-
Ru(bpy)
3
2+
NPs. The solid-state systemwas optimized using oxalate as a model compound. The amount of TiO
2
-Ru(bpy)
3
2+
NPs
and the effect of the oxidant flow rate were investigated. Subsequently, the optimized systemwas used to detect imipramine and
bromazine. A linear range was obtained for both drugs at concentrations 1-100 pm. This approach is considered simple, low
cost, facile and can be applied to a wide range of analytes.
Biography
Entesar Al-Hetlani completed her PhD in 2013 from Hull University, UK. She is an Assistant Professor at Kuwait University, Kuwait. Her research focuses on
nanomaterials synthesis and applications for Forensic and Analytical Applications.
Entesar_saad@hotmail.comEntesar Al-Hetlani et al., Insights in Analytical Electrochemistry, 3:2
DOI: 10.21767/2470-9867-C1-002