advanced-stem-cell-2018-posters-abstracts

Advanced Stem Cell 2018

Journal of Stem Cell Biology and Transplantation

ISSN: 2575-7725

Page 46

December 03-04, 2018

Valencia, Spain

Edition of EuroSciCon Conference on

Advanced Stem Cell &

Regenerative Medicine

ental pulpMethylprednisolone (MP), a glucocorticoid

steroid, has an anti-inflammatory action and seems to

inhibit the formation of oxygen free radicals produced during

lipid peroxidation in a spinal cord injury (SCI). Currently MP is

the standard therapy after acute SCI on reported neurological

improvements. The combination therapeutic effect of human

umbilical cord blood-derived mesenchymal stem cells (hUCB-

MSCs) for transplantation time (1d, 7d, and 30d) after MP

treatment on the axonal regeneration and on the behavioral

improvement in SCI were studied in the rat. The spinal cord was

injured by contusion using a weight-drop at the level of T9 and

MP (30 mg/kg, i.m., 10 min and 4 h) was acutely administered

after injury. hUCB-MSCs were labeled with GFP and our study

performed the efficacy for transplantation time (1d, 7d, and 30

d) of hUCB-MSCs into the boundary zone of injured site. Efficacy

was determined by histology, anterograde and retrograde tracing,

and behavioral test. We found that hUCB-MSCswithMP treatment

exerted a significant beneficial effect by neuroprotection and

reducing cavity volume. Also the transplantation of hUCB-MSCs

with MP treatment significantly improved functional recovery.

Combined transplantation at 7d after SCI provided significantly

greater efficiency than combined transplantation at 1d and 30d.

These results suggest that transplantation time window of the

hUCB-MSCs with MP treatment give rise to an earlier neuron

protection strategy and effect of cell grafting in SCI. Thus our

study may be considered as a therapeutic modality for SCI.

Effect of triiodothyronine on remyelination

enhancement after mesenchymal stem cell

intraperitoneal injection in c57bl/6 mice

cuprizone model of multiple sclerosis

Mohsen Marzban

and

Anahita Torkaman Boutorabi

Babol University of Medical Sciences, Iran

Tehran University of Medical Sciences, Iran

J Stem Cell Biol Transplant 2018, Volume 2

DOI: 10.21767/2575-7725-C1-003