7 / 29
World Nutrition 2018
J u n e 1 8 - 1 9 , 2 0 1 8
P a r i s , F r a n c e
Page 49
Journal of Clinical Nutrition & Dietetics
ISSN 2472-1921
W o r l d C o n g r e s s o n
Nutrition and Dietetics
C
QNQTGEVCN ECPEGT %4% YJKEJ KU QPG QH VJG OQUV EQOOQPN[
diagnosed cancers in developing and developed countries, is
highly associated with obesity. The association is largely attributed
to changes to western style diets in those countries containing high-
HCV CPF JKIJ GPGTI[ .WVGQNKP .76 KU C MPQYP RQVGPV KPJKDKVQT QH
inflammation, obesity, and cancer. In this study, we investigated the
effects of LUT on chemical-induced colon carcinogenesis in high fat
FKGV *(& HGF QDGUG OKEG (KXG YGGM QNF OCNG % $. OKEG TGEGKXGF
C UKPING KPVTCRGTKVQPGCN KPLGEVKQP QH C\QZ[OGVJCPG #1/ CV C FQUG
QH
OI MI DQF[ YGKIJV /KEG YGTG VJGP FKXKFGF KPVQ HQWT ITQWRU
P VJCV TGEGKXGF QPG QH VJG HQNNQYKPI FKGVU HQT YGGMU CHVGT VJG
#1/ KPLGEVKQP PQTOCN FKGV 0& *(& *(& YKVJ
.76 *(&
.. *(& YKVJ
.76 *(& *. 1PG YGGM CHVGT #1/ KPLGEVKQP
CPKOCNU TGEGKXGF ` FGZVTCP UQFKWO UWNHCVG KP VJGKT FTKPMKPI YCVGT
QXGT VJTGG E[ENGU EQPUKUVKPI QH ƒXG EQPUGEWVKXG FC[U GCEJ VJCV YGTG
separated by 16 days. Body weight and tumor multiplicity increased
UKIPKƒECPVN[ KP VJG *(& ITQWR EQORCTGF VQ VJG 0& ITQWR .76
UWRRNGOGPVCVKQP VQ VJG *(& UKIPKƒECPVN[ TGFWEGF VJG TCVKQ QH EQNQP
tumors, but not body weight. Immunohistochemistry analysis showed
that intestinal epithelial hyperplasia and proliferating cell nuclear
CPVKIGP 2%0# GZRTGUUKQP YCU FGETGCUGF D[ .76 +PVGTGUVKPIN[ VJG
NGXGNU QH RNCUOC KPUWNKP NKMG ITQYVJ HCEVQT +)( CPF EQNQPKE +)(
receptor protein increased in response to HFD, but were suppressed
by LUT supplementation. These results suggest that consumption of
LUT may reduce the risk of obesity-associated CRC by suppression of
colonocyte proliferation via IGF-1 signalling.
Dietary luteolin suppresses chemical induced colorectal
cancer proliferation in high fat diet fed mice
Jeong-eun Park and Eunjung Kim
Daegu Catholic University, Korea
Biography
Jeong-eun Park is a doctoral student in the department of food Science
and nutrition at Daegu Catholic University. Currently, she is investigating
on the mechanism of bioactive components extracted from mulberry
trees or traditional korean medicinal plants for the prevention of metabolic
diseases such as obesity, diabetes, and cancer.
babab07@naver.comJeong-eun Park et al., J Clin Nutr Diet 2018 Volume: 4
DOI: 10.4172/2472-1921-C1-003