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World Nutrition 2018
J u n e 1 8 - 1 9 , 2 0 1 8
P a r i s , F r a n c e
Page 47
Journal of Clinical Nutrition & Dietetics
ISSN 2472-1921
W o r l d C o n g r e s s o n
Nutrition and Dietetics
T
he demand of the herbal supplement for decreasing the risk of
diabetic nephropathy is increasing due to the increasing diabetes
and the crucial role on end stage of renal diseases of diabetic
nephropathy. Based on the crucial roles of oxidative stress and polyol
pathways on diabetic nephropathy, we hypothesized that the extract of
sacred lotus leaves possessing hypoglycemic, antioxidant and aldose
reductase suppression activities could prevent diabetic nephropathy.
To elucidate this issue, we aimed to determine the protective effect
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extract of sacred lotus leaves. The possible underlying mechanism
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I YGTG KPFWEGF
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sugar
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nephropathy effect. The extract of sacred lotus leaves at doses of 1.10
and 100 mg/kg were orally given to the experimental animals once daily
for 8 weeks. At the end of study, they were determined blood sugar,
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alterations of oxidative stress markers and renal histology were also
carried out. The extract at all doses used in this study could decrease
albumin urea and serum creatinine in diabetic rats. In addition, they
also improved histopathology of kidney. These data indicated that the
extract could improve pathology of kidney giving rise to the improved
kidney function. The principal mechanism of action might not occur
via the decreased oxidative stress in kidney. However, the précised
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The protective effect of sacred lotus leaves extract against
diabetic nephropathy
P Wannanon, J Wattananthorn and W Thukham-mee
ICAM R&D centre, Khon Kaen University, Thailand
Biography
P Wannanon is a Medical Doctor and she is the staff of Integrative
Complementary Alternative Medicine Research and Development Center
and Department of Physiology, Faculty of Medicine, Khon Kaen University,
Khon Kaen, Thailand. She has published more than 10 papers in reputed
journals.
wpanak@yahoo.comP Wannanon et al., J Clin Nutr Diet 2018 Volume: 4
DOI: 10.4172/2472-1921-C1-003