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World Nutrition 2018
J u n e 1 8 - 1 9 , 2 0 1 8
P a r i s , F r a n c e
Page 45
Journal of Clinical Nutrition & Dietetics
ISSN 2472-1921
W o r l d C o n g r e s s o n
Nutrition and Dietetics
O
besity during menopause is reported to increase the risk of
dementia. Accumulative lines of evidence have demonstrated
that both oxidative stress and apoptosis play the crucial role on
the neurodegeneration and memory impairment in the mentioned
condition. Recent study shows that protein supplementation decreases
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bean-derived protein on memory and neurodegeneration has gained
attention. Since no data are available, we aimed to determine the
neuroprotective and memory enhancement effects of mung bean-
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fed with high fat diet. The alterations of oxidative stress status and
apoptosis were also explored for the possible underlying mechanisms.
18: TCVU YGTG HGF YKVJ OWPI DGCP RTQVGKP HQT YGGMU CPF VJG
FGVGTOKPCVKQP QH OGOQT[ RGTHQTOCPEG CEGV[NEJQNKPGUVGTCUG #%J'
CEVKXKV[ QZKFCVKXG UVTGUU UVCVWU CPF VJG FGPUKV[ QH $CZ CPF $EN
stained cells in hippocampus and prefrontal cortex were carried out
at the end of study. It was found that mung bean-derived protein
supplementation enhanced both spatial memory and non-spatial
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cell density in both hippocampus and cerebral cortex. Therefore, the
reductions of oxidative stress status and apoptosis but increase in the
cholinergic function in hippocampus and prefrontal cortex were partly
responsible for the cognitive enhancement and neuroprotective effect
of mung bean-derived protein. These data suggest that mung bean-
derived protein may be served as the potential supplement to decrease
dementia risk for menopause with obesity. However, the clinical trial
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Mung bean-derived protein decreases memory impairment,
oxidative stress and neuronal apoptosis in hippocampus of
experimental menopause with obesity
S Muchimapura, W Mahasap, J Wattananthorn and W Thukham-mee
1
ICAM R&D Centre, Khon Kaen University, Thailand
Biography
Supaporn Muchmapura has completed her PhD from University
of Nottingham. She is the Head of Physiology Department, Faculty
of Medicine and also served as the Vice Director of Integrative
Complementary Alternative Medicine Research, Khon Kaen University,
Khon Kaen, Thailand. She has published more than 30 papers in reputed
journals and has many petty patents.
supmuc@kku.ac.thS Muchimapura et al., J Clin Nutr Diet 2018 Volume: 4
DOI: 10.4172/2472-1921-C1-003