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World Nutrition 2018
J u n e 1 8 - 1 9 , 2 0 1 8
P a r i s , F r a n c e
Page 46
Journal of Clinical Nutrition & Dietetics
ISSN 2472-1921
W o r l d C o n g r e s s o n
Nutrition and Dietetics
N
QP CNEQJQNKE HCVV[ NKXGT FKUGCUG 0#(.& KU CP KORQTVCPV JGCNVJ
DWTFGP KP VJG #UKC 2CEKƒE TGIKQP %WTTGPVN[ VJG OWNVK VCTIGV
approach has gained much attention because the pathophysiology
QH 0#(.& KPXQNXGU OCP[ HCEVQTU KPENWFKPI GRKIGPGVKE OQFKƒECVKQP
oxidative stress and inflammation. Therefore, we aimed to determine
the protective effect against NAFLD of ICAM61, the novel supplement
RQUUGUUKPI VJG OGPVKQPGF GHHGEVU KP DKNCVGTCN QXCTKGEVQOK\GF 18:
TCVU YKVJ OGVCDQNKE U[PFTQOG /GV5 (GOCNG 9KUVCT TCVU YGKIJKPI
I YGTG UWDLGEVGF VQ DKNCVGTCN QXCTKGEVQO[ #HVGT YGGM QH
surgery, they were induced MetS by a 20 week-high carbohydrate high
HCV FKGV *%*( HGGFKPI 6JG 18: TCVU YKVJ /GV5 UKIPU YGTG QTCNN[
IKXGP OQTRJKPG OKNNKITCO GSWKXCNGPVU //' CV FQUGU QH
CPF
OI MI $9 HQT YGGMU 6JGP VJG[ YGTG FGVGTOKPGF NKXGT JKUVQNQI[
and biochemical parameters including serum ALT and AST and the
GZRTGUUKQPU QH &0/6 22#4¸ 60( ¶ CPF 0( M$ KP NKXGT VQIGVJGT
YKVJ NKXGT QZKFCVKXG UVTGUU UVCVWU KPENWFKPI OCNQPFKCNFGJ[FG /&#
NGXGN CPF VJG CEVKXKVKGU QH UWRGTQZKFG FKUOWVCUG 51& INWVCVJKQPG
RGTQZKFCUG )5* 2Z CPF ECVCNCUG %#6 +V YCU HQWPF VJCV //'
FGETGCUGF 0#(.& #.6 #56 &0/6 /&# 60( ¶ CPF 0( M$ DWV
increased SOD, CAT, GSH-Px and PPAR-
¸
. Taken all together, MME
might exert hepatoprotective effect against NAFLD via the decreased
DNMT1 which in turn increased PPAR-
¸
and the decrease of TNF-
Ǖ
, NF-
kB resulting in the decreased inflammation. The decreased liver MDA
due to the elevations of SOD, CAT and GSH-Px also played the role.
*QYGXGT VJG ENKPKECN VTKCN VQ EQPƒTO VJKU GHHGEV KU UVKNN TGSWKTGF
ICAM61, the novel supplement, protects against the
steatohepatitis in menopause with metabolic syndrome via
epigenetic modification and the reductions of inflammation
and oxidative stress status
J Wattanathorn, S Kawvised and W Thukham-mee
ICAM R& D Centre, Khon Kaen University, Thailand
Biography
JWattanathorn has completed her PhD fromMahidol University. She is the
Director of Integrative Complementary Alternative Medicine Research and
Development Center, Faculty of Medicine (Khon Kaen University, Thailand).
She has published more than 45 papers in reputed journals and has been
serving as an Editorial Board Member of repute.
jinwat05@gmail.comJ Wattanathorn et al., J Clin Nutr Diet 2018 Volume: 4
DOI: 10.4172/2472-1921-C1-003