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World Nutrition 2018
J u n e 1 8 - 1 9 , 2 0 1 8
P a r i s , F r a n c e
Page 48
Journal of Clinical Nutrition & Dietetics
ISSN 2472-1921
W o r l d C o n g r e s s o n
Nutrition and Dietetics
N
eurodegeneration and cognitive dysfunction are regarded as the
important health problems in this decade and the supplements
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disturbances of neurotransmitters contribute the crucial roles on
neurodegeneration and memory impairment. Since visceral organs
of abalone are rich in many active compounds which are crucial for
brain functions and possesses antioxidant, we hypothesized that
the supplement containing visceral organs extract should protect
against age-related neurodegeneration and cognitive dysfunction.
Therefore, the supplement containing the extract of visceral organs of
abalone at doses of 1.10 and 100 mg/kg were orally given 28 days
DGHQTG CPF FC[U CHVGT VJG CFOKPKUVTCVKQP QH EJQNKPQVQZKP #( # XKC
intracerebroventricular route. At the end of study, memory performance,
neurons and cholinergic neurons densities, oxidative stress status and
VJG CEVKXKVKGU QH CEGV[NEJQNKPGUVGTCUG #%J' CPF OQPQCOKPG QZKFCUG
/#1 KP JKRRQECORWU YGTG FGVGTOKPGF 6JG TGUWNVU UJQYGF VJCV VJG
supplement at all doses used in this study could enhance memory and
the densities of both neurons and cholinergic neurons but decreased
oxidative stress status and the activities of both AChE and MAO in
hippocampus. Taken all data together, the novel supplement containing
the extract of visceral organs of abalone could protect against
neurodegeneration and cognitive dysfunction. The possible underlying
mechanism might occur partly via the improved cholinergic function
and oxidative stress status. The improvement of monoaminergic
system might also play a role on the enhanced cognitive function.
However, subchronic toxicity and clinical trial studies are still essential
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The neuroprotective and cognitive enhancing effects of the
novel supplement containing visceral organs extract of abalone
W Thukham-mee
1
, J Wattanathorn
2
and S Muchimapura
3
ICAM R&D centre, Khon Kaen University, Thailand
Biography
W Thukham-mee has been pursuing his PhD since 2012 from Khon
Kaen University. She is the staff and serve of the secretory of Integrative
Complementary Alternative Medicine Research and Development Center
and Department of Physiology, Faculty of Medicine, Khon Kaen University,
Khon Kaen, Thailand. She has published more than 10 papers in reputed
journals and has many petty patents.
meewe@gmail.comW Thukham-mee et al., J Clin Nutr Diet 2018 Volume: 4
DOI: 10.4172/2472-1921-C1-003